Researchers Identify Enzyme in Mice that May Contribute to Age-related Heart Disease

Article title: Loss of dynamic regulation of G protein-coupled receptor kinase 2 by nitric oxide leads to cardiovascular dysfunction with aging

Authors: Melissa Lieu, Christopher J. Traynham, Claudio de Lucia, Jessica Pfleger, Michela Piedepalumbo, Rajika Roy, Jennifer Petovic, Gavin Landesberg, Steven J. Forrester, Matthew Hoffman, Laurel A. Grisanti, Ancai Yuan, Erhe Gao, Konstantinos Drosatos, Satoru Eguchi, Rosario Scalia, Douglas G. Tilley, Walter J. Koch

From the authors: “This study uses a mouse model of chronic [G protein-coupled receptor kinase 2 (GRK2)] overactivity to further investigate the consequences of long-term GRK2 on cardiac function and structure. We report for the first time that chronic GRK2 overactivity was able to cause cardiac dysfunction and remodeling independent of surgical intervention, highlighting the importance of GRK activity in aged-related heart disease.” 

This study is highlighted as one of May’s “best of the best” as part of the American Physiological Society’s APSselect program.

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