The work of all three Laureates builds upon each other to show that oxygen sensing is a vital function across many cell types. Specifically, Dr. Semenza discovered a protein complex that binds to a DNA segment in an oxygen-dependent manner, which he named hypoxia-inducible factor (HIF). When oxygen sensing in cells fails or is interrupted because HIF cannot properly bind to DNA, it can lead to disease in many different areas of the body, depending on which cells are affected.
Dr. Semenza, who is the C. Michael Armstrong Professor of Pediatrics, Medicine, Oncology, Radiation Oncology, Biological Chemistry, and Genetic Medicine, is using his RPB grant to apply and extend the knowledge gained during his Nobel Prize-winning work to eye diseases that are characterized by extraneous blood vessel growth, or angiogenesis.
“We and others have shown the critical role of HIF in stimulating angiogenesis in the eye. With support from RPB, we are now developing HIF inhibitors as a potential therapy for ocular disorders that are associated with neovascularization, such as wet age-related macular degeneration and diabetic retinopathy,” said Dr. Semenza.
“We are so proud of Dr. Semenza’s incredible research accomplishments and are thrilled that with an RPB grant, he is focusing his Nobel-caliber knowledge and skills on the development of treatments for blinding eye diseases,” said RPB President Brian Hofland, PhD.
Dr. Semenza will receive his Nobel Prize in December 2019 at a ceremony in Sweden. His RPB Stein Innovation Award is active through the end of 2020.
To learn more about Dr. Semenza’s Nobel Prize in Medicine, visit https://www.nobelprize.org/prizes/medicine/. To learn more about his ongoing research, visit https://www.hopkinsmedicine.org/research/labs/gregg-semenza-lab.
About Research to Prevent Blindness
Research to Prevent Blindness (RPB) is the leading nonprofit organization supporting eye research directed at the prevention, treatment or eradication of all diseases that damage and destroy sight. As part of this purview, RPB also supports efforts to grow and sustain a robust and diverse vision research community. Since it was founded in 1960 by Dr. Jules Stein, RPB has awarded more than $368 million in research grants to the most talented vision scientists at the nation’s leading medical schools. As a result, RPB has been associated with nearly every major breakthrough in the understanding and treatment of vision loss in the past 50+ years. Learn more at www.rpbusa.org.
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