Protein Inhibitor May Lead to New Treatment for Low Oxygen Associated with Sleep Apnea

Article title: Lysine demethylase KDM6B regulates HIF-1α mediated systemic and cellular responses to intermittent hypoxia

Authors: Jayasri Nanduri, Ning Wang, Benjamin L. Wang, Nanduri R. Prabhakar

From the authors: “[The] current study demonstrates that pharmacological disruption of [Hypoxia-inducible factor]-1α activation with KDM6B inhibitor GSKJ4 might offer a novel therapeutic alternative for preventing cardiovascular morbidity caused by [intermittent hypoxia] associated with [obstructive sleep apnea].”

This study is highlighted as one of September’s “best of the best” as part of the American Physiological Society’s APSselect program.