Key Words: Cell survival, Cell therapy, Preconditioning, Pre-treatment, Stem cells, Super stem cells
Core Tip: Stem cell pre-treatment is a promising approach for accentuating their stemness and reparability and improving their resistance to apoptosis in the harsh microenvironment of the injured tissue. The current stem cell pre-treatment protocols allow for enhancing their therapeutic efficacy to surmount the limitations of mesenchymal stem cells (MSCs), i.e., mobility, survival, engraftment, and paracrine activity. Besides a novel sub-cellular preconditioning strategy, the combinative preconditioning approach exposing the cells to a proinflammatory milieu under hypoxia improves MSCs’ immunoregulatory potential. Refining a combinatorial pre-treatment protocol using a well-defined mechanistic understanding may allow the exploitation of the full benefits of the pre-treated “super MSCs” for enhanced stemness, functionality, and reparability, including immunosuppressive and immunomodulatory properties.
- Citation: Haider KH. Priming mesenchymal stem cells to develop “super stem cells”. World J Stem Cells 2024; 16(6): 623-640
- URL: https://www.wjgnet.com/1948-0210/full/v16/i6/623.htm
- DOI: https://dx.doi.org/10.4252/wjsc.v16.i6.623