Potential drug against antibiotic-resistant bacteria

Researchers report that the agent AB569, a combination of acidified nitrite and disodium ethylenediaminetetraacetic acid, killed Gram-negative and Gram-positive bacterial pathogens, including antibiotic-resistant bacteria, with high efficacy in lab tests; notably, AB569 not only neutralized Pseudomonas aeruginosa, a refractory pathogen implicated in numerous infections, including cystic fibrosis and chronic obstructive pulmonary disease, but also killed bacteria in biofilms and in a mouse model of chronic lung infection and was nontoxic to human cells at bactericidal concentrations, suggesting that AB569 represents a potential therapeutic agent for several human bacterial infections, according to the authors.

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Article # 19-11927: “AB569, a nontoxic chemical tandem that kills major human pathogenic bacteria ,” by Cameron T. McDaniel et al.

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