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UrduMetastatic colorectal cancer (mCRC) is a complex, heterogeneous disease characterized by multiple gene alterations that can significantly impact a patient’s prognosis and treatment option profile. Biomarker testing has transformed the landscape of mCRC care and is critical to ensuring a patient receives appropriate, evidence-based care. The goal of this project is to optimize biomarker-directed therapy based on established clinical practice guidelines in mCRC.
“Biomarker testing to determine optimal therapy in metastatic colorectal cancer can be complex, cumbersome, and prolonged, which leads to delays in appropriate patient care. These barriers exist throughout the biomarker testing continuum and include provider ordering, patient education, insurance coverage, tissue acquisition, data interpretation, and treatment implications” explained Crystal S. Denlinger, MD, FACP, Senior Vice President, Chief Scientific Officer, NCCN. “These investigators will hopefully provide research that leads to improving a key component of delivering guideline-concordant care.”
The selected projects are:
- Stacey A. Cohen, MD, Fred Hutchinson Cancer Center
- Implementation of a Rapid Assessment of Molecular Profiling of Metastatic Colorectal Cancer by Liquid Biopsy in Multi-Institutional Setting
- Amit Mahipal, MD, MPH and Melissa Lumish, MD, Case Comprehensive Cancer Center and University Hospitals Seidman Cancer Center
- Biomarker-driven and Evidence-Based Therapy for metastatic ColoRectal Cancer (BEAT-CRC): A System-Wide Initiative to Increase Access to Biomarker-Driven Therapy in a Large Practice
- Vanessa Wookey, MD, Fox Chase Cancer Center
- Improving Biomarker Testing in Patients with Metastatic Colorectal Cancer through Patient Education
“At Pfizer, we’re committed to raising awareness of both the importance of biomarker testing in mCRC as well as optimizing clinical implementation,” said Faisal Mehmud, MD, Precision Medicine & Early Pipeline Lead at Pfizer. “Improving access to biomarker testing as well as increasing our knowledge about testing methods are key to help improve outcomes for patients living with this type of devastating cancer. We are excited to partner with NCCN and Fight CRC on this project and are pleased to support three outstanding projects that have the potential to make a significant contribution in this important initiative.”
“Envisioning a future where metastatic colorectal cancer patients receive optimal and personalized treatment without unnecessary hurdles is at the heart of Fight CRC’s mission,” stated Anjee Davis, MPPA, President of Fight Colorectal Cancer (Fight CRC). “In partnership with Pfizer and NCCN, we are thrilled to reveal these transformative grants designed to dismantle barriers throughout the biomarker testing journey. Through a proactive approach in addressing patients’ challenges and expanding access to biomarker testing, we forge a path towards conquering this complex disease, all while empowering patients to become their own advocates in their fight for better outcomes.”
Proposals were peer reviewed by a Scientific Review Committee, which consisted of leading expert oncologists from NCCN Member Institutions. The selected projects are set to be completed within two years. Nearly $750,000 in funding will be provided across all grants.
The NCCN ORP fosters innovation and knowledge discovery that improve the lives of people with cancer and supports preclinical, translational, clinical research, and quality improvement projects in oncology at NCCN Member Institutions. In an effort to improve collaboration in cancer research, the NCCN ORP also maintains a shared resources website, an informed consent database, and points to consider on the best practices for biorepositories, registries, and databases. For more information, visit NCCN.org/orp.
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About the National Comprehensive Cancer Network
The National Comprehensive Cancer Network® (NCCN®) is a not-for-profit alliance of leading cancer centers devoted to patient care, research, and education. NCCN is dedicated to improving and facilitating quality, effective, equitable, and accessible cancer care so all patients can live better lives. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) provide transparent, evidence-based, expert consensus recommendations for cancer treatment, prevention, and supportive services; they are the recognized standard for clinical direction and policy in cancer management and the most thorough and frequently-updated clinical practice guidelines available in any area of medicine. The NCCN Guidelines for Patients® provide expert cancer treatment information to inform and empower patients and caregivers, through support from the NCCN Foundation®. NCCN also advances continuing education, global initiatives, policy, and research collaboration and publication in oncology. Visit NCCN.org for more information.
