Mouse Study Looks at Role of Transmembrane Transporter in Duchenne Muscular Dystrophy

Article title: Isoform-specific Na,K-ATPase and membrane cholesterol remodeling in motor endplates in distinct mouse models of myodystrophy

Authors: Violetta V. Kravtsova, Elena V. Bouzinova, Alexander V. Chibalin, Vladimir V. Matchkov, Igor I. Krivoi

From the authors: “Altogether, the α2 Na,K-ATPase and cholesterol abnormalities reported in this study can at least in part be a result of an adaptive skeletal muscle remodeling under chronic motor dysfunction. Further studies are necessary to identify detailed molecular basis of these changes and their functional significance. This knowledge could be useful in order to establish possible strategies for correction of these diseases.” 

This study is highlighted as one of June’s “best of the best” as part of the American Physiological Society’s APSselect program.

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