Mouse Study Explores Effect of Elastin Content on Age-related Vascular Remodeling

Article title: Elastin haploinsufficiency in mice has divergent effects on arterial remodeling with aging depending on sex

Authors: Jie Z. Hawes, Austin Cocciolone, Amy H. Cui, Diana B. Griffin, Marius Catalin Staiculescu, Robert P. Mecham, Jessica E Wagenseil

From the authors: “Our work provides comparative values for arterial mechanics and remodeling for young, to middle-aged, to old mice for males and females with varying elastin content. We demonstrate arterial remodeling that attempts to restore mechanical homeostasis with respect to circumferential wall stress, stretch and material stiffness.” 

This study is highlighted as one of December’s “best of the best” as part of the American Physiological Society’s APSselect program.