Supported by previous scientific evidence, the ARTIDIS atomic force microscopy (AFM) technology rapidly captures the physical properties of cells and their microenvironment at the nanometer level while preserving the tissue for future use. Within the scope of the alliance, MD Anderson and ARTIDIS researchers will collaboratively evaluate, using the ARTIDISNET platform, the combination of nano-scale physical properties of the tumor and corresponding clinical data to help identify biomarker signatures that suggest optimal therapeutic approaches.
Through collaboration with experts in MD Anderson’s Divisions of Radiation Oncology and Surgery, ARTIDIS expects to build evidence supporting subsequent regulatory submissions in solid tumors, with an initial focus on neoadjuvant applications for chemotherapy and radiotherapy/immunotherapy.
“As clinicians, we strive to gather as much evidence as possible to design a tailored treatment strategy for each patient. This technology gives us a distinct profile of the cancer that may provide unique insights about how to improve treatment outcomes for patients,” said principal investigator Eugene Koay, M.D., Ph.D., associate professor of Gastrointestinal Radiation Oncology at MD Anderson. “We are pleased to collaborate with the team at ARTIDIS to investigate their innovative nanotechnology platform, and we hope this effort will bring novel strategies to beat cancer.”
As part of the research alliance, MD Anderson and ARTIDIS researchers will work together on clinical utility studies to guide indications for the use of the device. The ARTIDIS team aims to pursue biomarker development avenues that will support the incorporation of ARTIDIS testing into national cancer guidelines and standards of care. MD Anderson clinicians will lead validation and proof-of-concept studies to evaluate the ARTIDIS technology as a tool for predicting response to treatment in multiple solid tumor indications.
“We are proud to collaborate with MD Anderson in the pursuit of demonstrating how the nanomechanical phenotypes of malignant tissues are highly predictive to indicate which tumors will metastasize and respond to treatment,” said Marija Plodinec, Ph.D., chief executive officer and co-founder of ARTIDIS. “Together we will work to actively drive optimal treatment options for patients with cancer.”
The strategic alliance with MD Anderson builds on a previous sponsored research agreement with James Welsh, M.D., professor of Radiation Oncology at MD Anderson, focusing on understanding immunotherapy resistance and response . Additionally, ARTIDIS has shown that nanomechanical alteration in cancer tissue is a potentially suitable marker for cancer aggressiveness and indicator of treatment response. This finding was clinically validated in a prospective study of 545 patients that used nanomechanical profiling to evaluate benign and malignant breast lesions. Moreover, ARTIDIS results suggested that nanomechanical changes may predict response rate and outcome of treatment.
Under the terms of the agreement, MD Anderson is eligible to receive payments based on the achievement of certain clinical milestones and commercial sales.
About ARTIDIS ARTIDIS AG is on a mission to shift the paradigm of cancer care from central lab to patient bedside by providing fast and precise diagnosis and prediction of treatment response immediately after the biopsy is taken. The clinical stage medical technology company located in Basel, Switzerland, has developed the first nanomechanical biomarker for cancer diagnosis and treatment optimization. Through generating these unique insights ARTIDIS is positioning its technology as a standard of care for tissue analysis and therapy optimization, thereby bringing benefits to both the patient and the healthcare system.
About MD Anderson The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world’s most respected centers focused on cancer patient care, research, education and prevention. The institution’s sole mission is to end cancer for patients and their families around the world. MD Anderson is one of only 53 comprehensive cancer centers designated by the National Cancer Institute (NCI). MD Anderson is No. 1 for cancer in U.S. News & World Report’s “Best Hospitals” rankings. It has been named one of the nation’s top two hospitals for cancer since the rankings began in 1990. MD Anderson receives a cancer center support grant from the NCI of the National Institutes of Health (P30 CA016672).