Low Oxygen at Birth Delays Heart Development in Mouse Model of Congenital Heart Disease

Article title: Chronic perinatal hypoxia delays cardiac maturation in a mouse model for cyanotic congenital heart disease

Authors: Jennifer Romanowicz, Devon Guerrelli, Zaenab Dhari, Colm Mulvany, Marissa Reilly, Luther Swift, Nimisha Vasandani, Manelle Ramadan, Linda Leatherbury, Nobuyuki Ishibashi, Nikki Gillum Posnack

From the authors: “Our results support our hypothesis that cardiac maturation is perturbed in a mouse model of chronic perinatal hypoxia. Chronic perinatal hypoxia altered both the electrophysiologic substrate and the contractile apparatus.” 

This study is highlighted as one of May’s “best of the best” as part of the American Physiological Society’s APSselect program.