High-Risk Pregnancy Specialists Analyze AI System to Detect Heart Defects on Fetal Ultrasound Exams

(New York, NY – January 23, 2025) – High-risk pregnancy specialists from the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai are presenting research at the Annual Pregnancy Meeting of the Society for Maternal-Fetal Medicine (SMFM) in Denver from January 27- February 1.

The Mount Sinai doctors are available for interview about their research findings, and can also provide commentary on other women’s health topics, breaking news, and studies.

PRESENTATIONS and POSTER SESSIONS
*All abstracts are under embargo until the below listed times*

Thursday, January 30, 2025

Oral Plenary Session 1
(4) AI Significantly Improves Detection of Prenatal Ultrasounds Suspicious for Major Congenital Heart Defects by OBGYN/MFMs
10:45 – 11:00 am ET / 8:45 – 9:00 am MT
Location: Aurora Ballroom, Lobby Level
Presenter: Jennifer Lam-Rachlin, MD, Assistant Clinical Professor in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai West
• Congenital heart defects are a leading cause of infant morbidity and mortality partly due to low prenatal detection rates. The researchers evaluated whether an artificial intelligence (AI) system can improve the detection of congenital heart defects on fetal ultrasound exams among both general OBGYNs and maternal fetal medicine specialists.

Poster Session 1
(156) The Philadelphia Urban ACE is associated with spontaneous preterm birth among Black pregnant individuals.
12:30 – 2:30 pm ET / 10:30 am – 12:30 pm MT
Presenter: Chelsea A. DeBolt, MD, MSCR, Assistant Professor in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai  
• Adverse childhood experiences—including physical, sexual, and verbal abuse and household dysfunction—associate with poor health across an individual’s life course. Evidence of associations with these exposure and adverse pregnancy outcomes are based on the traditional Kaiser ACE survey, which quantifies childhood adversity within the home. The Philadelphia Urban ACE survey expands on Kaiser ACE survey by incorporating community-level stressors derived from a more socioeconomically and racially diverse urban population. Mount Sinai researchers sought to assess associations between these surveys and spontaneous preterm birth among Black individuals.

Poster Session 1
(163) Examining psychometric screening scores for depression, anxiety, and post-traumatic stress after fetal KCL injection
12:30 – 2:30 pm ET / 10:30 am – 12:30 pm MT
Presenter: Daniel L. Kuhr, MD, Maternal Fetal Medicine Fellow at Mount Sinai  
Co-author: Nicola F. Tavella, MPH, Research Director for Maternal Fetal Medicine in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai
• This study examines the incidence of positive screens for depression, anxiety, and post-traumatic stress among patients undergoing therapeutic abortion at ≥ 22 weeks’ gestation.

Poster Session 1
(164) Examining the role of neighborhood level indices in predicting spontaneous preterm birth
12:30 – 2:30 pm ET / 10:30 am – 12:30 pm MT
Presenter: Daniel L. Kuhr, MD, Maternal Fetal Medicine Fellow at Mount Sinai  
Co-author: Nicola F. Tavella, MPH, Research Director for Maternal Fetal Medicine in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai
• Cervical length is an established, but limited, predictor of spontaneous preterm birth. The researchers examined whether measures of the neighborhood environment, which reflect structural determinants of pregnancy outcomes, improve prediction of spontaneous preterm birth as compared to cervical length alone.

Poster Session 1
(308) Gestational Lipid Profile and Perinatal Morbidity: A Pilot Study
12:30 – 2:30 pm ET / 10:30 am – 12:30 pm MT 
Presenter: Nicola F. Tavella, MPH, Research Director for Maternal Fetal Medicine in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai
• Lipid profile is a key metabolic predictor of risk related to perinatal morbidity. The study’s objective was to determine if gestational maternal lipids were associated with composite perinatal morbidity.

Poster Session 1
(346) Effects of antiretroviral therapy on fetal biometric measurements and neonatal weight
12:30 – 2:30 pm ET / 10:30 am – 12:30 pm MT  
Presenter: Sara E. Edwards, MD, Maternal Fetal Medicine Fellow at Mount Sinai Co-author: Angela Bianco, MD, Director of Maternal Fetal Medicine in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai  
• Several types of antiretroviral therapy used in the treatment of HIV, such as integrase inhibitors, have been linked to increased risk of metabolic syndrome in adults. This study assessed if these antiretroviral medications that cause metabolic syndrome in adults have similar effects on fetal weight and abdominal circumference when taken by HIV patients during pregnancy.

Oral Concurrent Session 3 – Ultrasound and Genetics
(30) Artificial Intelligence System Accurately Detects Fetal Ultrasound Findings Suspicious For Major Congenital Heart Defects
3:45 – 4:00 pm ET / 1:45 – 2:00 pm MT
Location: Aurora Ballroom, Lobby Level Co-authors: Jennifer Lam-Rachlin, MD, Assistant Clinical Professor in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai West; Andrei Rebarber, MD, Director of Maternal Fetal Medicine in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai West; Nathan S. Fox, MD, Clinical Professor in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai West
• Prenatal detection of congenital heart defects improves patient outcomes. Despite advances in imaging techniques and equipment, prenatal diagnosis remains low. The researchers evaluated the accuracy of an artificial intelligence (AI) system to detect second trimester ultrasound studies suspicious for congenital heart defects.

Oral Concurrent Session 2 – Clinical Obstetrics and Quality
(27) Hysterotomy using Barbed vs. Vicryl Suture for Scheduled Cesarean Delivery: A Randomized Controlled Trial
5:30 – 5:45 pm ET / 3:30 – 3:45 pm MT  
Location: Aurora Ballroom B, Lobby Level
Co-author: Nicola F. Tavella, MPH, Research Director for Maternal Fetal Medicine in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai
• Intraoperative reduction of blood loss correlates with reduced morbidity. The researchers examined whether Cesarean deliveries had significantly lower quantitative blood loss when the hysterotomy was closed with barbed suture.

Poster Session 2
(398) Unplanned Cesarean Delivery is Associated with Higher Risk of Postpartum Depression and Engagement in Care
6:00 – 8:00 pm ET / 4:00 – 6:00 pm MT 
Presenter: Alexandra N. Mills, MD, Maternal Fetal Medicine Resident at Mount Sinai Co-author: Nicola F. Tavella, MPH, Research Director for Maternal Fetal Medicine in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai
• Postpartum depression is a serious pregnancy complication, affecting 10-15 percent of postpartum people. Studies suggest an association between method of delivery and postpartum depression. Intrapartum experiences may contribute to postpartum depression development and affect patient engagement in healthcare after birth through attendance at the six-week postpartum visit. This study aims to interrogate the associations between method of delivery and postpartum depression, as well as postpartum visit attendance in a large national pregnancy dataset.

Poster Session 2
(499) The risk of ICP recurrence in the subsequent pregnancy: a retrospective analysis
6:00 – 8:00 pm ET /4:00 – 6:00 pm MT 
Presenter: Henri M. Rosenberg, MD, Maternal Fetal Medicine Fellow at Mount Sinai
• The recurrence risk of intrahepatic cholestasis of pregnancy, a liver condition, has been reported to be between 40-90 percent, based on small studies with homogeneous populations. The researchers’ objective was to determine the recurrence risk of intrahepatic cholestasis of pregnancy and identify variables associated with recurrence in a larger, more diverse population.

Poster Session 2
(651) Environmental protection agency (EPA) national walkability index: does it effect weight gain in GDM pregnancies?
6:00 – 8:00 pm ET / 4:00 – 6:00 pm MT 
Presenter: Thomas Owens, MD, Maternal Fetal Medicine Fellow at Mount Sinai West Co-author: Lois Brustman, MD, Vice Chair for Education and the Director of the Maternal-Fetal Medicine Fellowship in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai West
• An important factor in the management of gestational diabetes is exercise. The primary aim of this study was to assess neighborhood walkability and weight gain from time of diagnosis of gestational diabetes, and total weight gain of the pregnancy.

Poster Session 2
(652) Environmental protection agency (EPA) national walkability index and its impact on the severity of GDM
6:00 – 8:00 pm ET / 4:00 – 6:00 pm MT 
Presenter: Thomas Owens, MD, Maternal Fetal Medicine Fellow at Mount Sinai West
Co-author: Lois Brustman, MD, Vice Chair for Education and the Director of the Maternal-Fetal Medicine Fellowship in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai West
• An important factor in the management of gestational diabetes is exercise. The aim of this study is to assess neighborhood walkability and need for hypoglycemic agents in patients with gestational diabetes.

Friday, January 31, 2025
Poster Session 3
(822) Evaluating an Artificial Intelligence Platform Answering Common Pregnancy Questions: Satisfactory but Inconsistent.
12:30 – 2:30 pm ET / 10:30 am – 12:30 pm MT 
Presenter: Leonardo F. Antelo, MD, Resident at Mount Sinai West Co-author: Lois Brustman, MD, Vice Chair for Education and the Director of the Maternal-Fetal Medicine Fellowship in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai West
• The availability of artificial intelligence (AI) platforms is rapidly increasing. The researchers assessed the platform ChatGPT 3.0 and its ability to answer questions about common pregnancy conditions. This study analyzed the appropriateness of responses, the consistency of responses over multiple iterations, and the presence of misinformation within the responses.

Poster Session 4
(991) Poor periconceptional diet and sleep quality are associated with hypertensive disorders of pregnancy.
6:00 – 8:00 pm ET / 4:00 – 6:00 pm MT
Presenter: Chelsea A. DeBolt, MD, MSCR, Assistant Professor in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai  
• Hypertensive disorders of pregnancy remain a leading problem in the U.S. and risk factor for future adverse cardiovascular health. While recommendations to support long-term cardiovascular health exist for adults, specific lifestyle and wellness guidelines intended to improve pregnancy health are limited. The researchers sought to examine the relationship between periconceptional lifestyle-related factors, including nutrition, sleep, and physical activity and development of hypertensive disorders of pregnancy.

Poster Session 4
(992) Is the Timing of Gestational Diabetes Screening Associated with Adverse Perinatal Outcomes?
6:00 – 8:00 pm ET / 4:00 – 6:00 pm MT
Presenter: Chloe Getrajdman, MD, MSCR, Resident at Mount Sinai Co-author: Chelsea A. DeBolt, MD, MSCR, Assistant Professor in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai 
• Though there is a universal recommendation to screen for gestational diabetes from 24-28 weeks, the impact of the timing of screening within this 5-week interval has yet to be studied.  The study objective was to determine whether the gestational age of 2-step gestational diabetes screening among those diagnosed with gestational diabetes is associated with adverse outcomes.

Poster Session 4
(993) Is Time Between Screening and Diagnosis of Gestational Diabetes Associated with Adverse Outcomes?
6:00 – 8:00 pm ET / 4:00 – 6:00 pm MT
Presenter: Chloe Getrajdman, MD, MSCR, Resident at Mount Sinai Co-author: Chelsea A. DeBolt, MD, MSCR, Assistant Professor in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai 
• This study determines whether the interval between gestational diabetes screening glucose challenge test and diagnostic glucose tolerance test is associated with adverse perinatal outcomes.

Poster Session 4
(1183) Monogeneic Disorder (MD) Screening using Cell-Free DNA (cfDNA) In Routine Practice
6:00 – 8:00 pm ET / 4:00 – 6:00 pm MT
Presenter: Xiteng Yan, MD, Maternal Fetal Medicine Fellow at Mount Sinai West Co-author: Andrei Rebarber, MD, Director of Maternal Fetal Medicine in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai West
• More pregnancies are affected by monogeneic disorder than by trisomy 21. Monogeneic disorder are often not identified on ultrasound, standard invasive testing, or microarray. Clinical studies of cfDNA detection of monogeneic disorder report >99% sensitivity and specificity, with a 1:600 incidence of positive results in a high-risk population. The researchers sought to determine (1) the feasibility of offering routine cfDNA for monogeneic disorder, (2) false positive rate of monogeneic disorder diagnosed at the time of cfDNA for aneuploidy, and (3) accuracy of cfDNA for monogeneic disorder when routinely offered to low-risk patients.

Poster Session 4
(1206) Is first trimester hemorrhage with concurrent anemia associated with placenta accreta spectrum?
6:00 – 8:00 pm ET / 4:00 – 6:00 pm MT
Presenter: Tess E.K. Cersonsky, MD, Resident at Mount Sinai
Co-author: Angela Bianco, MD, Director of Maternal Fetal Medicine in the Raquel and Jaime Gilinski Department of Obstetrics, Gynecology and Reproductive Science at the Icahn School of Medicine at Mount Sinai  
• First trimester hemorrhage may contribute to abnormal placentation. These abnormalities can have devastating consequences in the form of placenta accreta spectrum, which is associated with significant maternal morbidity and mortality. Subchorionic hematoma, a leading cause of first trimester hemorrhage, and anemia may contribute to placental hypoxia and aberrant placentation. The researchers sought to establish if an association exists between anemia, hemorrhage, and placenta accreta spectrum. 

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