The widespread stomach pathogen
is attracted to bleach, according to new research by Arden Perkins of the University of Oregon in Eugene, Oregon, and colleagues. These findings published on August 29 in the open-access journal
) is found in the stomachs of about 50 percent of all humans. While most people show no symptoms, the bacterium can cause gastritis, ulcers, and even stomach cancer. Previous research has shown that an
protein known as transducer-like protein D (TlpD) is required for the bacterium to efficiently colonize the stomach, but the molecular function of TlpD has been unclear.
The authors of the new study hypothesized that TlpD might respond to hypochlorous acid (HOCl), commonly known as bleach. At sites of inflammation in the stomach, certain cells naturally produce bleach as an antimicrobial defense, but some microbes, including
, hijack the system by strategically navigating to these sites of inflammation and persisting there.
To examine how bleach might affect TlpD and influence
navigation, the researchers first performed a series of biochemical experiments outside of living cells. They found that bleach causes a specific change in the molecular shape of TlpD, and this shape change appears to serve as a signal that is transmitted to other proteins involved in
Additional experiments with
cells showed that the bacterium is indeed attracted to bleach, and that a functional TlpD protein is required for this attraction. The researchers also found that
is highly resistant to bleach.
These findings suggest that bleach-sensing by TlpD enables
to turn the body’s defenses to its own advantage by helping it to seek out inflamed stomach tissue for colonization. Further research will be needed to clarify the role of bleach in
Peer-reviewed Experimental Study Bacteria
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Citation: Perkins A, Tudorica DA, Amieva MR, Remington SJ, Guillemin K (2019)
senses bleach (HOCl) as a chemoattractant using a cytosolic chemoreceptor.
Funding: Research reported in this publication was supported by the National Institutes of Health (
), NIDDK under award numbers R01DK101314 5 (S.J.R., M.R.A and KG.), and F32DK115195 (A.P.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing Interests: The authors have declared that no competing interests exist.
This part of information is sourced from https://www.eurekalert.org/pub_releases/2019-08/p-csb083019.php