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EMBARGOED UNTIL OCTOBER 8, 2019, 12:00 AM EDT
The Effectiveness of Electrical Stimulation in Producing Spinal Fusion
Detailed findings of this study can be found in a new article, “The effect of electrical stimulation therapies on spinal fusion: a cross-disciplinary systematic review and meta-analysis of the preclinical and clinical data,” by Ethan Cottrill and colleagues, published today in the Journal of Neurosurgery: Spine (https://thejns.org/doi/full/10.3171/2019.5.SPINE19465).
Background: Each year in the United States approximately 400,000 persons undergo spinal fusion surgery for spinal instability, pain, and/or loss of function. For some of these people, surgery alone does not produce complete spinal fusion. In those cases, adjuvant therapies must be instituted to aid in the process of bone healing.
One of these therapies is electrical stimulation. There are three types of electrical stimulation therapy in use today: direct current stimulation, capacitive coupling stimulation, and inductive coupling stimulation (also known as pulsed electromagnetic field).
Direct current stimulation requires implantation of a stimulation device, which is usually done at the time of spinal fusion surgery. The device is small and is placed under the skin on the patient’s back. Via electrodes, the device delivers a small direct current of electricity to the area where fusion needs to occur. The battery powering the device is good for 6 to 12 months; after that time, it can be removed or remain in place as the patient or physician deems appropriate.
Capacitive and inductive coupling stimulation therapies are noninvasive. With capacitive coupling stimulation, two small electrode pads are placed on the skin over the region of desired bone fusion. These pads produce an electrical field surrounding that region when powered by an external alternating current generator. This device is worn by the patient for 6 to 9 months and operates approximately 24 hours per day. Inductive coupling stimulation involves the use of electromagnetic coils placed on the skin over the site of anticipated bone fusion. Alternating current produces an electromagnetic field to induce bone fusion. This device need only be used for 30 minutes to 2 hours per day until fusion is confirmed.
Each therapy has a particular mechanism of action and carries advantages and disadvantages. These are all described and compared in the paper by Cottrill and colleagues.
Present Study: Application of direct or alternating electrical current has been shown to induce and speed up the process of bone healing following spine fusion surgery. Evidence for this has come from small studies. Cottrill and colleagues set out to pool the data from small studies on the effects of electrical stimulation therapies and to comprehensively assess these effects overall and in specific subgroups.
The authors performed a systematic review of all English-language articles describing the effects of electrical stimulation therapies on spinal bone fusion. Applying specific inclusion criteria, they narrowed the studies down to 17 preclinical and 16 clinical studies. Meta-analyses of data from all of the studies that included a control group were also performed (11 preclinical studies [257 animals] and 13 clinical studies [2,144 patients]).
The authors found, overall, that electrical stimulation was effective at augmenting spinal fusion. They found nearly a fivefold increase in the odds of successful bone fusion in animals and a greater than twofold increase in patients treated with electrical stimulation therapy.
With respect to the various types of stimulation therapy, the authors found that in animals the effects of direct current stimulation on spinal fusion were very beneficial, whereas the effects of inductive coupling stimulation were little different from no electrical stimulation at all. (No preclinical studies involved the use of capacitive coupling stimulation.) In humans, both direct current stimulation and inductive coupling stimulation were highly effective in aiding spinal fusion. The authors were unable to find a difference in efficacy between these two types of electrical stimulation therapies. Only one study of capacitive coupling stimulation therapy in humans fit the inclusion criteria of the systematic review, and that paper showed no statistically significant difference between fusion rates in patients who received electrical stimulation and those who did not (control group).
In a subgroup analysis of clinical studies, the authors found that the number of spinal levels that were fused and whether instrumentation was used did not change the effectiveness of electrical stimulation devices. They also found that these devices improved the rates of fusion in patient groups prone to have difficulty in achieving total spinal fusion, such as patients with difficult-to-treat spines and smokers.
When asked about the importance of the study, the senior author, Daniel Sciubba, MD, said, “We were surprised by how large an effect these therapies have on spinal fusion. It was also encouraging to see that the preclinical data aligned with the clinical evidence, which supports future translational research efforts in spine surgery. Ultimately, we hope our findings will help to inform patients and providers to enhance outcomes following spinal fusion.”
Cottrill E, Pennington Z, Ahmed AK, Lubelski D, Goodwin ML, Perdomo-Pantoja A, Westbroek EM,Theodore N, Witham T, Sciubba D: The effect of electrical stimulation therapies on spinal fusion: a cross-disciplinary systematic review and meta-analysis of the preclinical and clinical data. J Neurosurg Spine, published ahead of print October 8, 2019. DOI: 10.3171/2019.5.SPINE19465.
Disclosure: Dr. Goodwin reports being a consultant for Augmedics and ROM3, having an ownership stake in AOSpine/NREF, and receiving textbook royalties from Kendall Hunt. Dr. Theodore receives royalties from DePuy and Globus Medical Inc.; he is a consultant for Globus. Dr. Witham reports receiving non–study-related grant support from the Gordon and Marilyn Macklin Foundation and from Eli Lilly and Company; he is a consultant for DePuy Synthes Spine. Dr. Sciubba is a consultant for Baxter, DePuy Synthes, Globus, K2M, Medtronic, NuVasive, and Stryker. Mr. Cottrill reports receiving non–study-related grant support from the National Institute on Aging (F30AG063445).
For additional information, contact: Ms. Jo Ann M. Eliason, Communications Manager, JNS Publishing Group, One Morton Drive, Suite 200, Charlottesville, VA 22903; Email [email protected]; Phone 434-982-1209.
The Journal of Neurosurgery: Spine is a monthly peer-reviewed journal focused on neurosurgical approaches to treatment of diseases and disorders of the spine. It contains a variety of articles, including descriptions of preclinical and clinical research as well as case reports and technical notes. The Journal of Neurosurgery: Spine is one of five journals published by the JNS Publishing Group, the scholarly journal division of the American Association of Neurological Surgeons. Other peer-reviewed journals published by the JNS Publishing Group include the Journal of Neurosurgery, Journal of Neurosurgery: Pediatrics, Neurosurgical Focus, and Neurosurgical Focus: Video. All five journals can be accessed at www.thejns.org.
Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with more than 10,000 members worldwide. The AANS is dedicated to advancing the specialty of neurological surgery in order to provide the highest quality of neurosurgical care to the public. All active members of the AANS are certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons (Neurosurgery) of Canada or the Mexican Council of Neurological Surgery, AC. Neurological surgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the entire nervous system including the brain, spinal column, spinal cord, and peripheral nerves. For more information, visit www.AANS.org.
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