The NCCN 2023 Annual Conference took place in-person in Orlando and virtually, with a particular focus on human connection. That connection was underscored with more than 2,000 registrants from across the continuum of cancer care, including approximately 1,000 who returned in-person for the first time since 2019. Educational sessions highlighted the importance of ensuring care meets the latest standards while also rejecting a one-size-fits-all approach.