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Researchers at Institut Fresnel have developed an Extended Depth-of-Field Random Illumination Microscope (EDF-RIM) that integrates 3D speckle illumination for super-resolved imaging and extended depth detection for faster acquisition of thick samples. EDF-RIM captures entire 3D volumes in a single projection, reducing acquisition time and light exposure.
Scientists developed a new method to improve resolution and reduce noise in fluorescence microscopy images. This technique utilizes mathematical tools to analyze and enhance image details, specifically addressing the fidelity of computational resolution extension. It outperforms existing methods by boosting signal-to-noise ratio and achieving higher resolution without introducing artifacts. This paves the way for more precise and informative imaging in various microscopy applications.
There are various ways to image biological samples on a microscopic level, and each has its own pros and cons. For the first time, a team of researchers, including those from the University of Tokyo, has combined aspects from two of the leading imaging techniques to craft a new method of imaging and analyzing biological samples.
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