Mathematical Model Driven Evolutionary Therapy Dosing Exploiting Cancer Cell Plasticity

A research team led by Dr. Kim Eunjung at the Natural Products Informatics Research Center of the Korea Institute of Science and Technology (KIST) has established a theoretical foundation for cancer treatment strategies following tumor evolution. They have developed a mathematical model to predict tumor evolution, considering the acquisition of resistance by cancer cells and their ability to alter phenotypic behavior (plasticity) during treatment.