Study IDs New Potential Therapeutic Targets to Protect against Muscle Atrophy

Article title: Phosphorylation of ERK and dystrophin S3059 protect against inflammation-associated C2C12 myotube atrophy

Authors: Kristy Swiderski, Christopher J. Brock, Jennifer Trieu, Annabel Chee, Savant S. Thakur, Dale M. Baum, Paul Gregorevic, Kate T. Murphy, Gordon S. Lynch

From the authors: “Utilizing in vitro models of inflammation-associated atrophy in C2C12 myotubes, we showed both [dystrophin serine 3059] phosphorylation, and increased [extracellular signal-regulated kinases] activation, to be a potential therapeutic target for attenuating muscle atrophy.” 

This study is highlighted as one of May’s “best of the best” as part of the American Physiological Society’s APSselect program.