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UrduThe U.S. Centers for Disease Control and Prevention recommends presumptive treatment of individuals with symptoms of or known contact with these infections to decrease likelihood of secondary infections as well as poor outcomes.
The healthcare settings of all 18 of the studies reviewed were within the U.S. and patients were age 14 and older. Presumptive treatment rates were found to differ both geographically and within care settings such as emergency departments or clinics. The reviewers noted that race and ethnicity were inconsistently reported in the studies.
Chlamydia and gonorrhea are the two most common sexually transmitted infections in the U.S. While treatment decisions are dependent on individual clinician discretion, the CDC Sexually Transmitted Diseases Treatment Guidelines include recommendations for treatment of either of the two diseases before confirmation of infection.
“Test results for chlamydia and gonorrhea aren’t available at the time of a medical visit, so patients can be lost to follow-up if not treated at the time of testing, increasing the potential for chlamydia and gonorrhea to be untreated and to spread,” said review senior author Brian Dixon, PhD, MPA, the interim director of Regenstrief Institute’s Center for Biomedical Informatics and director of public health informatics at Regenstrief and Indiana University Fairbanks School of Public Health. “In the U.S., we have very high rates of sexually transmitted diseases, and especially during the pandemic, increasing rates of sexually transmitted disease activity. This has a lot of negative consequences, especially for pregnant women and babies, so we should be presumptively treating.”
Chlamydia and gonorrhea are the two most common notifiable sexually transmitted diseases in the U.S. Effective and timely treatment is critical to avoid potential future complications related to ongoing infection, including pelvic inflammatory disease and ectopic pregnancy in women, and infertility in both women and men. Both diseases are often asymptomatic in women.
“When we looked at the data from the studies, we saw rates of presumptive treatment for some areas that were very low, but for some that were very high. When averaged out, we saw roughly 42 percent. One emergency department was presumptively treating 84 percent while another ED was proactively treating at a much, much lower rate,” said Katie Allen, B.S., a Regenstrief data scientist who is corresponding author of the study. “It’s important to get into the nuances and figure out not only where variation is occurring, but also, why its occurring. Most of the 18 studies we reviewed focused on urban areas and also didn’t consider social determinants of health, which might be impactful.”
The review highlights the need to:
- Create communication vehicles to persuade individuals to seek clinical care for sexually transmitted diseases.
- Develop antibiotic stewardship strategies for clinical application.
- Encourage greater discussion of policy as well as clinical questions focused on populations and sub-populations.
Having surveyed presumptive care for chlamydia and gonorrhea landscape in this review, the Regenstrief researchers are currently analyzing data on presumptive treatment of chlamydia and gonorrhea from the Indiana Network for Patient Care, one of the nation’s oldest and largest health information exchanges. This study will go beyond existing studies of presumptive care, which typically focus on one clinic or healthcare system, to examine care of chlamydia and gonorrhea by multiple health systems in metropolitan Indianapolis, one of the largest metro areas in the country.
“Findings from a Scoping Review: Presumptive Treatment for Chlamydia Trachomatis (CT) and Neisseria Gonorrhoeae (GC) in the USA, 2006-2021” is published in the peer-reviewed journal Sexually Transmitted Diseases.
This work was supported by a contract from the U.S. Centers for Disease Control and Prevention (CDC).
Author list from the publication:
Katie S Allen1, Rachel Hinrichs2, Christine L. Heumann3, Melissa K. Titus4, Thomas J. Duszynski4, Nimish R Valvi1, Ashley Wiensch1, Guoyu Tao5, Brian E Dixon1,4
Author affiliations from the publication:
1 Regenstrief Institute, Inc.
2 Indiana University Purdue University Indianapolis.
3 Indiana University School of Medicine.
4 Richard M. Fairbanks School of Public Health, IUPUI.
5 Centers for Disease Control and Prevention.
About Brian E. Dixon, PhD, MPA
In addition to his roles as interim director of the Regenstrief Institute’s Clem McDonald Center for Biomedical Informatics and director of public health informatics for Regenstrief Institute and Indiana University Richard M. Fairbanks School of Public Health, Brian E. Dixon, PhD, MPA is a professor of epidemiology at the Fairbanks School of Public Health. He is also an affiliate scientist at the U.S. Department of Veterans Affairs Health Services Research and Development Center for Health Information and Communication, Richard L. Roudebush VA Medical Center.
About Katie Allen
Katie Allen is a data scientist at Regenstrief Institute, adjunct faculty at Indiana University Richard M. Fairbanks School of Public Health (FSPH) and a doctoral student in health policy and management at FSPH. She has experience as a senior program manager in health services research at the Richard L. Roudebush VA Medical Center and as a program manager for LOINC® from Regenstrief, short for Logical Observation Identifiers Names and Codes, a worldwide healthcare data interoperability standard used in nearly every country in the world.
About Regenstrief Institute
Founded in 1969 in Indianapolis, the Regenstrief Institute is a local, national and global leader dedicated to a world where better information empowers people to end disease and realize true health. A key research partner to Indiana University, Regenstrief and its research scientists are responsible for a growing number of major healthcare innovations and studies. Examples range from the development of global health information technology standards that enable the use and interoperability of electronic health records to improving patient-physician communications, to creating models of care that inform practice and improve the lives of patients around the globe.
Sam Regenstrief, a nationally successful entrepreneur from Connersville, Indiana, founded the institute with the goal of making healthcare more efficient and accessible for everyone. His vision continues to guide the institute’s research mission.
About the Richard M. Fairbanks School of Public Health
Located on the IUPUI and Fort Wayne campuses, the Richard M. Fairbanks School of Public Health is committed to advancing the public’s health and well-being through education, innovation and leadership. The Fairbanks School of Public Health is known for its expertise in biostatistics, epidemiology, cancer research, community health, environmental public health, global health, health policy and health services administration.
