The researchers analyzed data from fifty 10-year-old children from a community in Cape Town, South Africa, that has among the highest rates of FASD in the world. The children were examined by experts for signs of FAS and PFAS, and information on prenatal drinking was collected from their mothers while they were pregnant. Place-learning skills were evaluated with a computer-based water maze task. This task involved learning the location of a hidden platform in a virtual pool of water, using fixed cues (different objects) on the virtual room walls to help navigate to the platform from different starting positions. A few days later, participants had an MRI brain scan in a child-friendly university neuroimaging center to assess hippocampal size.
Of the fifty participants, 9 children were diagnosed with FAS or PFAS, 22 had been heavily exposed to alcohol in utero but did not exhibit the physical abnormalities of FAS or PFAS, and 19 had no (or minimal) PAE. The MRI scans showed that children whose mothers drank heavily in pregnancy had a smaller hippocampus (relative to other brain regions) on the right side of the brain than those with no or minimal PAE – regardless of whether they had a diagnosis of FAS or PFAS. Smaller hippocampal size and, as expected, PAE were also associated with poorer place-learning skills in the water maze task. Using statistical modeling, the team was able to show that the relation between PAE and performance on the water maze was due, in part, to reduced hippocampal size. These findings suggest that PAE impairs children’s ability to encode spatial information necessary for place learning, enhancing scientists’ understanding of the far-reaching effects of PAE on the developing brain.
Reduced Hippocampal Volumes Partially Mediate Effects of Prenatal Alcohol Exposure on Spatial Navigation on a Virtual Water Maze Task in Children. N.C. Dodge, K.G.F. Thomas, E.M. Meintjes, C.D. Molteno, J.L. Jacobson, S.W. Jacobson (pages xxx).
ACER-20-4279.R1.
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