Prior research suggests that certain drugs affect how leukemia metabolism works, so researchers explored if changing a person’s diet could be beneficial. In testing different diets on mice with leukemia, researchers found that mice eating food without the amino acid called histidine lived longer. In this project, investigators will examine mice with leukemia and samples from real patients to see how histidine affects cancer. They will also explore if combining histidine restriction with current treatments works even better.
The project will take place over a four-year period.