Oncotarget
published ”
A higher De Ritis ratio (AST/ALT) is a risk factor for progression in high-risk non-muscle invasive bladder cancer
” which reported that a recent study revealed that a high De Ritis ratio was a risk factor in some solid malignancies.
This
Oncotarget
study examined the importance of the De Ritis ratio as a prognostic marker in high-risk NMIBC.
This
Oncotarget
study examined the importance of the De Ritis ratio as a prognostic marker in high-risk NMIBC
Among these patients, 32 patients developed recurrent disease and 15 patients showed progression.
A multivariate analysis revealed that non-BCG treatment was an independent risk factor for recurrence, and a higher De Ritis ratio was an independent risk factor for cancer progression.
The De Ritis ratio might be a risk factor for progression in high-risk NMIBC.
The De Ritis ratio might be a risk factor for progression in high-risk NMIBC
Dr. Takashi Kawahara from
The Yokohama City University Medical Center
said, ”
Bladder cancer is the eleventh most common malignant disease in the world, and non-muscle invasive bladder cancer (NMIBC) accounts for 75% of all bladder cancer cases.
”
The serum aspartate aminotransaminase /alanine aminotransaminase ratio was first reported by De Ritis in 1957, since then this ratio has been called
the De Ritis ratio
.
A high De Ritis ratio was reported to be a poor prognostic marker in some solid malignancies.
In genitourinary cancer, a high De Ritis ratio was reported to be a poor prognostic marker in prostate, renal, and urothelial carcinoma.
In other solid malignancies including breast and lung cancer, a high De Ritis ratio was also reported to be a poor prognostic marker.
This study examined the importance of the De Ritis ratio as a prognostic marker in high-risk NMIBC.
The Kawahara Research Team concluded in their
Oncotarget Research Output
that first, the study was retrospective in nature.
To reveal the usefulness of the De Ritis ratio as a biomarker, a longer-term study of a larger population with a prospective design should be performed.
Third, this study showed higher age in the higher De Ritis group.
No previous study showed the correlation between AST/ALT value and age.
Thus, further study is needed.
###
DOI
–
https:/
/
doi.
org/
10.
18632/
oncotarget.
27944
Full text
–
https:/
/
www.
oncotarget.
com/
article/
27944/
text/
Correspondence to
– Takashi Kawahara –
[email protected]
Keywords
–
AST
,
ALT
,
De Ritis
,
high risk NMIBC
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This part of information is sourced from https://www.eurekalert.org/pub_releases/2021-05/ijl-opi051721.php