Scientists Identify Mouse Model to Study Heart and Lung Function at High Altitude

Article title: Transcriptomic modifications in developmental cardiopulmonary adaptations to chronic hypoxia using a murine model of simulated high-altitude exposure

Authors: Sheila Krishnan, Robert S. Stearman, Lily Zeng, Amanda Fisher, Elizabeth A. Mickler, Brooke H. Rodriguez, Edward R. Simpson, Todd Cook, James E. Slaven, Mircea Ivan, Mark W. Geraci, Tim Lahm, Robert S. Tepper

From the authors: “The consistency of our animal model with human data generates a strong potential to evaluate molecular mechanisms of adaption to chronic hypoxia that will then assist in identifying novel targets and pathways for the treatment of cardiopulmonary diseases related to chronic hypoxia.” 

This study is highlighted as one of September’s “best of the best” as part of the American Physiological Society’s APSselect program.