Unlocking the medicinal potential of Lotus BIAs: Advances in research for future drug development

A research team has made process in understanding benzylisoquinoline alkaloids (BIAs) in lotus (Nelumbo nucifera), highlighting their presence in various tissues and their potential for novel drug development. The team’s review covers chemical profiling, extraction methods, pharmacological activities, and biosynthesis of lotus BIAs, noting the identification of 59 BIAs, with a focus on their accumulation in leaves and plumules. The review underscores the importance of these compounds in treating life-threatening diseases, such as obesity, inflammation, cancer, HIV, and aniocardiopathy, and outlines the need for future research in the functional characterization of biosynthetic pathways and structural modifications of BIAs. This work not only deepens our understanding of lotus BIAs, but also lays a foundation for its application to create effective clinical drugs and solves the urgent need for the treatment of degenerative disease and new infections

Lotus (Nelumbo nucifera), commonly known as the Asian lotus, holds significant commercial and cultural value. Lotus is rich in benzylisoquinoline alkaloids (BIAs) in almost all tissues and has great potential for developing new drugs to prevent and treat a variety of life-threatening diseases. However, it is still a challenge to optimize the extraction of these compounds, explore their pharmacological potential and elucidate their biosynthetic pathways.

 Addressing these challenges, a study (DOI: 10.48130/vegres-0024-0004) published in Vegetable Research on 05 February 2024, provides a comprehensive summary on the up-to-date advances in the study of lotus BIAs.

Researchers have methodically advanced our understanding of the biosynthesis, chemical profiling, extraction methods, and pharmacological activities of BIAs in the lotus plant. Their findings reveal that lotus plants are enriched in more than 61 BIAs, predominantly classified into the 1-benzylisoquinoline, aporphine, and bis-BIA categories, with significant accumulation in leaves and plumules, and presenting a unique predominance of R-conformers in contrast to the S-conformers commonly found in the Ranunculales order. Some BIAs such as nuciferine and anonaine showing significant pharmacological potential. Extraction methods such as supercritical fluid extraction and high-speed counter-current chromatography increase yields and purity. High-performance liquid chromatography combined with electrospray ionization and tandem mass spectrometry remains the gold standard for BIA separation, quantification and characterization. Pharmacological studies of these compounds have highlighted their potential in the treatment of various diseases ranging from obesity to cancer due to their multiple biological activities.

Furthermore, the dynamic accumulation of BIAs in lotus has been intricately studied, and the results showed that there were significant differences in BIA content at different developmental stages and among different lotus cultivars. .Based on the isolation and functional characterisation of the biosynthetic genes, the key biosynthetic pathways of BIAs in lotus were proposed, revealing the crucial steps from tyrosine conversion to the formation of complex BIA structures. The regulation of these pathways and the transcriptional mechanisms governing BIA biosynthesis have been explored, indicating a sophisticated control system influenced by mechanical wounding and jasmonate treatment.

According to the study’s lead researcher, Prof. Xianbao Deng, “This review provides a comprehensive summary on the up-to-date advances in the chemical profiling, extraction methods, pharmacological activities, and biosynthesis of lotus BIAs.”

This comprehensive research not only enriches our understanding of the lotus BIAs but also opens avenues for future research and potential clinical applications, including the development of novel drugs targeting life-threatening human diseases.

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References

DOI

10.48130/vegres-0024-0004

Original Source URL

https://doi.org/10.48130/vegres-0024-0004

Authors

Xue Wei1 , Minghua Zhang2,5 , Mei Yang2,3,4 , Collins Ogutu6 ,Jing Li1* and Xianbao Deng2,3,4*

Affiliations

1 School of Chemistry, Chemical Engineering and Life Sciences, Wuhan University of Technology, Wuhan 430070, China

2 Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China

3 Aquatic Plant Research Center, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China

4 Hubei Key Laboratory of Wetland Evolution & Ecological Restoration, Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, China

5 University of Chinese Academy of Sciences, 19A Yuquanlu, Beijing 100049, China

6 Fraunhofer Institute for Process Engineering and Packaging IVV, 85354 Freising, Germany