Article title: DPP4 deletion in adipose tissue improves hepatic insulin sensitivity in diet-induced obesity
Authors: Tania Romacho, Henrike Sell, Ira Indrakusuma, Diana Roehrborn, Tamara R. Castañeda, Tomas Jelenik, Daniel Markgraf, Sonja Hartwig, Jürgen Weiß, Hadi Al-Hasani, Michael Roden, Jürgen Eckel
From the authors: “Taken together, circulating [dipeptidyl peptidase 4 (DPP4)] is upregulated in obese rodents, and its downregulation improves hepatic insulin resistance likely by modulating insulin-like growth factor-binding protein 3, rendering adipose DPP4 as a new therapeutic target in hepatic insulin resistance.”
This study is highlighted as one of March’s “best of the best” as part of the American Physiological Society’s APSselect program.
Original post https://alertarticles.info
