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AACC Releases Guidance on Procalcitonin Testing to Improve Care for Patients with Bacterial Infections

WASHINGTON—AACC has issued expert guidance on clinical testing for procalcitonin, a blood marker that helps detect serious bacterial infections and sepsis. By giving clinicians and laboratory professionals much-needed clarity on how to best use procalcitonin tests, the new guidelines could improve the treatment of critically ill patients and those with certain lower respiratory infections.

Read the guidance document here: https://www.aacc.org/science-and-research/aacc-academy-guidance/clinical-use-of-procalcitonin

Procalcitonin tests have been used for many years in Europe, but only became available in the United States in 2017, when the Food and Drug Administration (FDA) approved them as tools to help guide antibiotic treatment and predict which patients are most likely to die within 28 days of being diagnosed with sepsis (also known as 28-day mortality risk). Due to the newness of procalcitonin tests in the U.S., there is still confusion about when to use them, and they are often ordered in situations where they are not clinically appropriate. AACC’s new guidance provides a rigorous examination of the research evaluating procalcitonin along with an analysis of its limitations, with the goal of facilitating better testing and treatment.  

Specifically, the guidance document addresses key questions related to the use of procalcitonin to manage adult, pediatric, and newborn patients with suspected sepsis and/or bacterial infections, particularly lower respiratory tract infections. It also explores the evidence for using these tests to guide antimicrobial treatment decisions and predict patient outcomes.

Major conclusions from the guidance document are as follows:

“Improved outcomes from [procalcitonin] implementation are more likely to be realized when the test is used in conjunction with antimicrobial stewardship programs, institutional interpretive algorithms, and clinical decision support tools,” said the guidance document authors Drs. Allison B. Chambliss, Khushbu Patel, Jessica M. Colón-Franco, Joshua Hayden, Sophie E. Katz, Emi Minejima, and Alison Woodworth. “Successful implementation of clinical [procalcitonin] requires a multidisciplinary effort among laboratorians, pharmacists, and infectious disease providers.”

About AACC

Dedicated to achieving better health through laboratory medicine, AACC brings together more than 70,000 clinical laboratory professionals, physicians, research scientists, and business leaders from around the world focused on clinical chemistry, molecular diagnostics, mass spectrometry, translational medicine, lab management, and other areas of progressing laboratory science. Since 1948, AACC has worked to advance the common interests of the field, providing programs that advance scientific collaboration, knowledge, expertise, and innovation. For more information, visit www.aacc.org.