A new machine learning approach detects esophageal cancer better than current methods

LEBANON, NH – Recently, deep learning methods have shown promising results for analyzing histological patterns in microscopy images. These approaches, however, require a laborious, high-cost, manual annotation process by pathologists called “region-of-interest annotations.” A research team at Dartmouth and Dartmouth-Hitchcock Norris Cotton Cancer Center, led by Saeed Hassanpour, PhD, has addressed this shortcoming of current methods by developing a novel attention-based deep learning method that automatically learns clinically important regions on whole-slide images to classify them.

The team tested their new approach for identifying cancerous and precancerous esophagus tissue on high-resolution microscopy images without training on region-of-interest annotations. “Our new approach outperformed the current state-of-the-art approach that requires these detailed annotations for its training,” concludes Hassanpour. Their results, “Detection of Cancerous and Precancerous Esophagus Tissue on Histopathology Slides Using Attention-Based Deep Neural Networks” will publish in

JAMA Network Open

in early November, 2019.

For histopathology image analysis, the manual annotation process typically outlines the regions of interest on a high-resolution whole slide image to facilitate training the computer model. “Data annotation is the most time-consuming and laborious bottleneck in developing modern deep learning methods,” notes Hassanpour. “Our study shows that deep learning models for histopathology slides analysis can be trained with labels only at the tissue level, thus removing the need for high-cost data annotation and creating new opportunities for expanding the application of deep learning in digital pathology.”

The team proposed the network for Barrett esophagus and esophageal adenocarcinoma detection and found that its performance exceeds that of the existing state-of-the-art method. “The result is significant because our method is based solely on tissue-level annotations, unlike existing methods that are based on manually annotated regions,” says Hassanpour. He expects this model to open new avenues for applying deep learning to digital pathology. “Our method would facilitate a more extensive range of research on analyzing histopathology images that were previously not possible due to the lack of detailed annotations. Clinical deployment of such systems could assist pathologists in reading histopathology slides more accurately and efficiently, which is a critical task for the cancer diagnosis, predicting prognosis, and treatment of cancer patients.”

Looking ahead, Hassanpour’s team is planning to validate their model further by testing it on data from other institutions and running prospective clinical trials. They also plan to apply the proposed model to histological images of other types of tumors and lesions for which training data are scarce or bounding box annotations are not available.

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Saeed Hassanpour, PhD, is an associate professor of Biomedical Data Science and associate professor of Epidemiology at Dartmouth’s Geisel School of Medicine, associate professor of Computer Science at Dartmouth’s College of Arts and Sciences, and member of the Cancer Population Science Research Program at Dartmouth and Dartmouth-Hitchcock Norris Cotton Cancer Center. His research interests include biomedical informatics, machine learning, and personalized medicine.

https:/

/

www.

hassanpourlab.

com/

About Norris Cotton Cancer Center at Dartmouth-Hitchcock

Norris Cotton Cancer Center combines advanced cancer research at Dartmouth’s Geisel School of Medicine with patient-centered cancer care provided at Dartmouth-Hitchcock Medical Center in Lebanon, NH, at Dartmouth-Hitchcock regional locations in Manchester, Nashua and Keene, NH, and St. Johnsbury, VT, and at partner hospitals throughout New Hampshire and Vermont. It is one of 51 centers nationwide to earn the National Cancer Institute’s “Comprehensive Cancer Center” designation. Learn more about Norris Cotton Cancer Center research, programs, and clinical trials online at

cancer.dartmouth.edu

.