Article title: Western diet induces renal artery endothelial stiffening that is dependent on the epithelial Na+ channel
Authors: Yuxin Xiong, Annayya R. Aroor, Francisco I. Ramirez-Perez, Guanghong Jia, Javad Habibi, Camila Manrique-Acevedo, Guido Lastra, Donqqing Chen, Vincent G. DeMarco, Luis A. Martinez-Lemus, Michael A. Hill, Frederic Jaisser, James R. Sowers, Adam Whaley-Connell
From the authors: “These results demonstrate that cell-specific EnNaC is important in propagating pulsatility into the renal circulation, generating oxidant stress, reduced bioavailable [nitric oxide], and renal vessel wall fibrosis and stiffening.”
This study is highlighted as one of June’s “best of the best” as part of the American Physiological Society’s APSselect program.
Original post https://alertarticles.info
