Article title: Skeletal muscle-specific calpastatin overexpression mitigates muscle weakness in aging and extends life span
Authors: Elizabeth A. Schroder, Lin Wang, Yuan Wen, Leigh Ann P. Callahan, Gerald S. Supinski
From the authors: “These data suggest that diaphragm dysfunction in aging may be a major factor in determining longevity. Targeting the calpain/calpastatin pathway may elucidate novel therapies to combat skeletal muscle weakness in aging.”
This study is highlighted as one of September’s “best of the best” as part of the American Physiological Society’s APSselect program.
