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Resilience and challenges: Evaluating the impact of stress conditions on mesenchymal stem cells across different passages

sarah Jonas

This article discussed a study by Almahasneh et al, which investigated how high glucose and severe hypoxia affected mesenchymal stem cells (MSCs) at different passages. This research provides insights into the resilience of higher-passage MSCs under stress conditions, challenging the common use of lower passage MSCs in clinical settings. While this study offers valuable perspectives on the adaptability of MSCs, it relies mainly on in vitro results from a single cell line, limiting broader applicability. It highlights the need for more comprehensive in vivo studies to validate these findings and better understand MSC behavior in clinical scenarios.

Key Words: Mesenchymal stem cells; High glucose; Hypoxia; Cellular senescence; Passages

Core Tip: This article discussed the research by Almahasneh et al on the resilience of mesenchymal stem cells (MSCs) under high glucose and severe hypoxia conditions at different passages. Highlighting the adaptability of higher passage MSCs, this study challenges traditional preferences for lower passage MSCs for use in clinical treatments, especially under conditions simulating diabetic or ischemic environments. While offering novel insights into MSC adaptability are offered, the research’s reliance on in vitro tests from a single cell line highlights the need for more in-depth in vivo studies to ascertain the clinical relevance of these findings and broaden their applicability.