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ACR, BCRF and GE Healthcare Announce Trial to Evaluate Use of Contrast Enhanced Mammography for Screening Women with Dense Breasts

Chicago (Dec. 2, 2019) – In a new effort to improve early breast cancer detection and reduce false positive exams in women with dense breasts, the American College of Radiology (ACR), Breast Cancer Research Foundation (BCRF) and GE Healthcare are partnering to support the Contrast Enhanced Mammography Imaging Screening Trial (CMIST).

The planned trial, managed by the ACR Center for Research and Innovation, seeks to determine if contrast enhanced spectral mammography (CESM) screening provides more accurate cancer detection compared to combination of digital breast tomosynthesis (DBT) and whole breast ultrasound (WBUS) in women with dense breasts.

Approximately 40 percent of women age 40 and over have dense breasts, which can make detection of breast cancer more challenging using mammography alone. With wider digital breast tomosynthesis (DBT) adoption, and increased use of supplemental screening ultrasound due to breast density notification laws, many women with dense breasts are screened each year with both DBT and whole breast ultrasound (WBUS).

“CMIST will investigate the challenges of current screening options for women with dense breasts,” said Dorraya El-Ashry, PhD, BCRF Chief Scientific Officer. “The goal is to reduce false positive rates while improving breast cancer detection. Early detection remains key to improving breast cancer outcomes and our collective goal is to optimize critical tools for diagnosis.” 

CESM combines mammography and vascular-based screening methods that may offer a more efficient screening approach. CESM highlights areas of unusual blood flow patterns in a simple and quick procedure. Early studies of CESM in screening women with dense breasts have shown that CESM has the potential to increase the breast cancer detection rate by 70-80% compared to conventional mammography.[1] 

Expected to launch in spring 2020, the paired-design multicenter trial will evaluate the performance of CESM in screening women with mammographically dense breasts (BI-RADS density categories c and d), ages 40-75, at average-to-intermediate risk for breast cancer, compared to the combination of tomosynthesis and ultrasound. 

“The new CMIST Trial can help determine if CESM can provide a more accurate and efficient screening approach for women with dense breasts,” said CMIST Principal Investigator Christopher Comstock, MD, FACR, FSBI, director of breast imaging clinical trials, Memorial Sloan Kettering Cancer Center. 

“We know that one size does not fit all when it comes to breast care, and that it’s critical to offer a personalized approach to breast cancer screening,” says Agnes Berzsenyi, President and CEO of Women’s Health at GE Healthcare. “We’re excited to support this important study to further evaluate the clinical benefits of CESM so that clinicians can be even more confident in their diagnosis and quickly get answers for their patients.” 

To speak with a CMIST representative, contact American College of Radiology Public Affairs Director Shawn Farley at 703-648-8936 or PR@acr.org. 

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About the American College of Radiology The American College of Radiology is a membership organization of 39,000 radiologists, radiation oncologists and medical physicists dedicated to serving patients and society by empowering radiology professionals to advance the practice, science and professions of radiological care

About BCRF

The Breast Cancer Research Foundation (BCRF) is dedicated to ending breast cancer by advancing the world’s most promising research. Founded by Evelyn H. Lauder in 1993, BCRF-funded investigators have been deeply involved in every major breakthrough in breast cancer prevention, diagnosis, treatment, survivorship and metastasis. BCRF is the largest private funder of breast cancer research worldwide.

About GE Healthcare

GE Healthcare is the $19.8 billion healthcare business of GE (NYSE: GE). As a leading provider of medical imaging, monitoring, biomanufacturing, and cell and gene therapy technologies, GE Healthcare enables precision health in diagnostics, therapeutics and monitoring through intelligent devices, data analytics, applications and services. With over 100 years of experience in the healthcare industry and more than 50,000 employees globally, the company helps improve outcomes more efficiently for patients, healthcare providers, researchers and life sciences companies around the world. Follow us on Facebook, LinkedIn, Twitter and The Pulse for latest news, or visit our website https://corporate.gehealthcare.com/ for more information.

[1] Sung et al. Radiology Oct 2019

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