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Tag: Type 2 Diabetes
Nitrite additives associated with increased risk of type 2 diabetes
Nitrites and nitrates occur naturally in water and soil and are commonly ingested from drinking water and dietary sources. They are also used as food additives to increase shelf life. A study published on January 17th in PLOS Medicine suggests an association between dietary exposure to nitrites and risk of type 2 diabetes.
Study Explores Effects of Resistance Training in Older Adults at the Cellular Level
Aging and related diseases are associated with alterations in oxidative status and low-grade inflammation, as well as a decreased endoplasmic reticulum (ER) unfolded protein response (UPR). UPR is a functional mechanism by which cells attempt to protect themselves against ER stress. Researchers analyzed these proteins in peripheral blood mononuclear cells of elderly subjects and used computer simulation to predict the key proteins associated with these biomolecules underlying physiological adaptations to exercise. They collected blood samples about five to six days before and after the training period and analyzed various oxidative stress biomarkers in peripheral blood mononuclear cells. The study takes research one step further in helping to elucidate the benefits of exercise in this population.
Study reveals obesity-related trigger that can lead to diabetes
Researchers at Washington University School of Medicine in St. Louis have found that a defect in an enzyme called APT1 interferes with the ability to secrete insulin, contributing to the development of Type 2 diabetes in people who are overweight or obese.
Poor glycemic control in patients with type 2 diabetes can be predicted from patient information systems with the help of machine learning
The risk for poor glycemic control in patients with type 2 diabetes can be predicted with confidence by using machine learning methods, a new study from Finland finds.
Intermittent fasting may reverse type 2 diabetes
After an intermittent fasting diet intervention, patients achieved complete diabetes remission, defined as an HbA1c (average blood sugar) level of less than 6.5% at least one year after stopping diabetes medication, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism.
Low-carb diet may help patients with diabetes achieve better weight loss and glucose control in short term compared to a low-fat diet
A randomized controlled trial of more than 100 persons with type 2 diabetes found that a low-carbohydrate, high-fat, calorie unrestricted diet helped patients achieve better weight loss and glucose control over a 6-month intervention compared to a high-carb, low-fat diet. The changes were not sustained 3 months after the intervention, suggesting a need for long-term dietary changes to maintain meaningful health benefits. The findings are published in Annals of Internal Medicine.
Let the patient choose their type 2 diabetes medication says research study
A largescale new study offers a new approach to treating in type 2 diabetes – that puts patients in charge of their own medication.
It’s not them, it’s you: Why potatoes don’t deserve their bad reputation
With low or no-carbohydrate diets rising in popularity in recent times, the humble potato is now regularly overlooked in favour of other vegetables.
Dapagliflozin reduces risk for hospitalization in patients with CKD with or without diabetes
Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reduced the risk for hospitalization for any cause in patients with chronic kidney disease (CKD) with and without type 2 diabetes.
‘You can always make a change’: 15-Year-Old Johns Hopkins Patient with Type 2 Diabetes Thrives Almost 2 Years After Diagnosis
November is National Diabetes Awareness Month. Youth onset type 2 diabetes is rising worldwide, and a recent study by researchers at Johns Hopkins Children’s Center, published in the Journal of Pediatrics, documented a steep rise in new diagnoses of type 2 diabetes among children during the early part of the COVID-19 pandemic
Type 2 diabetes genes linked with gestational diabetes in South Asian women
The same complex genetics that contribute to a higher risk of type 2 diabetes may also increase the risk of developing diabetes during pregnancy among women of South Asian descent, a study published today in eLife shows.
Two Couples, Two Kidneys—and All Heart
This Thanksgiving, when the Moraleses think about what they’re thankful for, the Thompsons are at the top of the list.
Detecting the undetected: measuring levels of three proteins in the blood can aid detection of undiagnosed prediabetes
Scientists have used a proteomics approach to identify a three-protein signature in the blood that can improve detection of isolated impaired glucose tolerance, a form of prediabetes.
Alzheimer’s disease and type 2 diabetes: Synthetic peptides may suppress formation of harmful amyloid aggregates
In Alzheimer’s disease, the degeneration of brain cells is linked to formation of toxic protein aggregates and deposits known as amyloid plaques.
SGLT2 inhibitors and GLP1 receptor antagonists improve type-2 diabetes outcomes, but are not cost effective
A cost-effectiveness study of sodium–glucose cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP1) receptor agonists has found that the use of these medications as first-line treatment for type-2 diabetes would improve outcomes, but their costs would need to decrease by at least 70 percent to be cost-effective. The study is published in Annals of Internal Medicine.
New study explains link between diabetes and UTIs
Lower immunity and recurring infections are common in type 1 and type 2 diabetes.
Significant Boost in Rates of Type 2 Diabetes Among Children During COVID-19 Pandemic
In a multi-site study of medical records, researchers at Johns Hopkins Children’s Center and across the United States say they have documented a steep rise in type 2 diabetes among children during the COVID-19 pandemic.
UCI-led study shows Rhodiola rosea root might be beneficial for managing type 2 diabetes
A team of researchers led by the University of California, Irvine has discovered that treatment with an extract from the roots of the Rhodiola rosea plant might be effective for helping manage type 2 diabetes, showing promise as a safe and effective non-pharmaceutical alternative. The study, recently published online in Scientific Reports, found that in a mouse model of human type 2 diabetes, Rhodiola rosea lowered fasting blood sugar levels, improved response to insulin injections, modulated the composition of bacteria in the gastrointestinal tract and decreased several biomarkers of inflammation.
Lactating Mice Pass along Common Antimicrobial to Pups, Initiating Liver Damage
In mouse studies, UC San Diego researchers report that lactating mothers expose their feeding pups to triclosan, an antimicrobial commonly used in consumer products, resulting in early signs of liver damage.
Vitamin B5 May Help Weight Loss by Turning on Brown Fat
Pantothenate acid, also known as vitamin B5, stimulated the production of brown fat in both cell cultures and mice, a new study finds. “[B5] has therapeutic potential for treating obesity and type II diabetes,” researchers conclude. The study was chosen as an APSselect article for July.
A Rhythmic Small Intestinal Microbiome Prevents Obesity and Type 2 Diabetes
UC San Diego researchers found that in mice how much they ate and when altered the nature of their gut microbiome: too much food too frequently resulted in poorer microbial and metabolic health.
New discoveries about enzyme’s metabolic role may lead to better diabetes treatments
For the first time, a team led by UAH, a part of the University of Alabama System, has characterized the metabolic function of a phosphatase enzyme called mitogen-activated protein kinase phosphatase-2 (MKP-2), as well as the enzyme’s pathophysiology in obesity, Type 2 diabetes and nonalcoholic fatty liver disease.
Vitamin D Supplements May Offset Bone Loss Caused by Diabetes Drug
Vitamin D supplementation may help offset damaging bone loss that occurs in some people who take canagliflozin, a commonly prescribed diabetes drug. Researchers will present their work this week at the American Physiological Society (APS) and American Society for Nephrology Control of Renal Function in Health and Disease conference in Charlottesville, Virginia.
Pediatric Liver Disease Increases Risk of Developing Type 2 Diabetes
UC San Diego researchers describe connection between pediatric liver disease and increased risk of developing type 2 diabetes. Both rates are rising in children.
Addressing stress and postpartum symptoms early may reduce risk for type 2 diabetes in women with gestational diabetes
Addressing stress early on in postpartum women who recently experienced gestational diabetes might help curb an increased risk for type 2 diabetes, according to research being presented Sunday, June 12 at ENDO 2022, the Endocrine Society’s annual meeting in Atlanta, Ga.
Traditional native Indian medicine is effective in treatment of type 2 diabetes, says new study
A new study, led by experts at the University of Nottingham, has found that several traditional medicines commonly used in South Asia, are effective in maintaining blood sugar levels in patients with type 2 diabetes.
The Paired Perils of Breast Cancer and Diabetes
UC San Diego researchers discover mechanism linking breast cancer and diabetes, each of which promotes development and growth of the other.
Protein Supplement Helps Control Type 2 Diabetes
Drinking a small amount of whey protein before meals has been shown to help people with type 2 diabetes control their blood sugars.
Leader in Diabetes Care and Technologies Joins Cedars-Sinai
Roma Gianchandani, MD, has joined Cedars-Sinai as the new medical director of Diabetes Quality and vice-chair of Quality and Innovation.
Epigenetic markers predict complications in patients with type 2 diabetes
A new study by researchers at Lund University in Sweden supports the notion that patients with type 2 diabetes patient should be divided into subgroups and given individualised treatment.
Drug That Lowers Blood Sugar Also Reduces Blood Vessel Dysfunction Caused by Aging
An FDA-approved drug to lower blood sugar in adults with Type 2 diabetes also may decrease blood vessel dysfunction associated with aging, according to a new study from the University of Missouri School of Medicine.
Type 2 diabetes accelerates brain aging and cognitive decline
Scientists have demonstrated that normal brain aging is accelerated by approximately 26% in people with progressive type 2 diabetes compared with individuals without the disease, reports a study published today in eLife.
Common diabetes drug not effective against early-stage breast cancer, landmark trial reveals
A widely used and inexpensive Type 2 diabetes drug, once hoped to hold enormous promise in treating breast cancer, does not prevent or stop the spread of the most common forms of the disease, according to new findings.
Lifestyle changes, meds effective to prevent or delay Type 2 diabetes; no change in CVD
A lifestyle intervention program of increased physical activity, healthy eating and aiming for weight loss of 7% or more, or taking the medication metformin were effective long-term to delay or prevent Type 2 diabetes in adults with prediabetes.
A healthy lifestyle helps to prevent gestational diabetes in those at highest genetic risk
Gestational diabetes is the most common health-related challenge during pregnancy. Today, it is diagnosed in every fifth expectant mother in Finland.
Reducing sedentary time mitigates the risk of type 2 diabetes and cardiovascular diseases
A new study suggests that reducing daily sedentary time can have a positive effect on the risk factors of lifestyle diseases already in three months.
Retrospective study finds that cancer drug also lowers blood glucose
Dasatinib, a drug that often is used to treat certain types of leukemia, may have antidiabetic effects comparable to medications used to treat diabetes, and with more research may become a novel therapy for diabetic patients, according to new research published in Mayo Clinic Proceedings.
High Availability of Fast-Food Restaurants Across All U.S. Neighborhood Types Linked to Higher Rates of Type 2 Diabetes, New Study Finds
A new nationwide study led by researchers from NYU Grossman School of Medicine published online today in JAMA Network Open suggests that living in neighborhoods with higher availability of fast-food outlets across all regions of the United States is associated with higher subsequent risk of developing type 2 diabetes.
Personalized medicine research focuses on Hispanics with diabetes in South Texas
A team of researchers studying genetic data to identify hormone responses in a population of Mexican Americans with prediabetes, Type 2 diabetes, and obesity recently received a $3.5 million grant to fund a five-year study set to begin in late 2021.
Sweet! How Glycogen is Linked to Heat Generation in Fat Cells
University of California San Diego researchers, with international colleagues, describe how energy expenditure and heat production are regulated in obesity through a previously unknown cellular pathway.
A Cure for Diabetes?
Technion researchers are working on a novel treatment approach for treating type 2 diabetes using an autograft of muscle cells engineered to take in sugar at increased rates. Mice treated in this manner displayed normal blood sugar levels for months after a single procedure.
UNLV Research Bolsters Link Between Diabetes and Alzheimer’s Disease
In a study published in the September issue of the journal Communications Biology, UNLV neuroscientists show that chronic hyperglycemia impairs working memory performance and alters fundamental aspects of working memory networks.
UCLA-led Research Finds Ozone Exposure Link to the Development of Type 2 Diabetes
UCLA-led research finds ozone exposure contributes to the development of Type 2 diabetes; team examining Californians’ health finds pattern holds true, particularly among those with higher levels of leisure-time outdoor physical activity
Project to improve health equity in Indianapolis expands with funding from Lilly
Indiana University has received a five-year, $5 million grant from Eli Lilly and Co. to expand the Diabetes Impact Project, which aims to improve health equity in three Indianapolis neighborhoods where residents are predominantly people of color.
How migraines protect against diabetes
People who get migraines are less likely to develop type 2 diabetes. Today, scientists report the latest findings about the relationship between insulin production and the peptides that cause migraine pain. They will present their results at ACS Fall 2021.
Do Some Diabetes Drugs Reduce the Risk of Alzheimer’s?
MINNEAPOLIS – People taking certain drugs to lower blood sugar for type 2 diabetes had less amyloid in the brain, a biomarker of Alzheimer’s disease, when compared to both people with type 2 diabetes not taking the drugs and people without diabetes. The new study, published in the August 11, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology, also found people taking these drugs, called dipeptidyl peptidase-4 inhibitors, showed slower cognitive decline than people in the other two groups.
Frequent Breaks from Sitting May Improve Daily Blood Sugar Fluctuations
Frequent activity breaks from sitting may improve fasting blood sugar (glucose) levels and stabilize daily fluctuations, according to new research. The study, the first of its length to explore the effects of activity breaks in “free-living” conditions, is published ahead of print in the American Journal of Physiology-Endocrinology and Metabolism. It was chosen as an APSselect article for August.
No more finger pricks: a continuous glucose monitor benefits patients with diabetes in more ways than one
For adults with type 2 diabetes, pairing basal insulin with continuous glucose monitoring improved blood sugar and quality of life.
International experts call for a unified public health response to NAFLD and NASH epidemic
Patients with obesity or type 2 diabetes are at a higher risk of developing NAFLD and NASH.