English
Arabic
Chinese (Simplified)
Dutch
Esperanto
French
German
Greek
Italian
Japanese
Korean
Portuguese
Russian
Spanish
UrduCoriell Life Sciences is rolling out a new tool in the fight against COVID-19: personalized COVID-19 Risk Scores designed to enable safer re-opening and return to work plans (especially given the recent release of the CDC guidelines for re-opening).
Tag: Precision Medicine
Calibrated approach to AI and deep learning models could more reliably diagnose and treat disease
In a recent preprint (available through Cornell University’s open access website arXiv), a team led by a Lawrence Livermore National Laboratory computer scientist proposes a novel deep learning approach aimed at improving the reliability of classifier models designed for predicting disease types from diagnostic images, with an additional goal of enabling interpretability by a medical expert without sacrificing accuracy. The approach uses a concept called confidence calibration, which systematically adjusts the model’s predictions to match the human expert’s expectations in the real world.
Moving Precision Medicine From Evaluation Into Practice and Policy
Value in Health announced today the publication of a series of articles focused on methods for moving from the evaluation of precision medicine into practice and policy.
Researchers Identify Mechanism to Explain Role of Certain Gene Mutations in Kidney Disease
Researchers from the Center for Precision Disease Modeling at the University of Maryland School of Medicine (UMSOM) have uncovered a mechanism that appears to explain how certain genetic mutations give rise to a rare genetic kidney disorder called nephrotic syndrome. Using a drosophila (fruit fly) model, they found mutations in genes that code for certain proteins lead to a disruption of the recycling of the cell membrane.
Henry Ford Health System Receives $25 Million Gift, Largest Single Donation in its History
Nationally-known developer Chris Jeffries and his wife Lisa have donated $25 million to Henry Ford Health System, the largest single gift from an individual in the health system’s 105-year history. This historic gift will rapidly accelerate the growth and expansion of Henry Ford’s Precision Medicine program, with the ultimate goal of creating a Precision Health Center. The efforts will have a robust focus on the advancement of cancer research and treatment, while also expanding to other medical specialties treating behavioral health, cardiovascular and metabolic diseases.
PECASE Honoree Sohini Ramachandran Studies the Genetic Foundations of Traits in Diverse Populations
NIGMS grantee and presidential award recipient Sohini Ramachandran, Ph.D., is challenging our understanding of genetic variation among human populations. She discusses her research on how the genetic composition of traits and diseases varies among populations, the value of statistical and computational work in human genetics, and what this all means for patient treatment.
Coriell Researchers Identify SNP Associated with Obesity Risk
Obesity is among the most common complex diseases in the United States and has been a stubborn public health challenge for decades. Its causes are wide ranging, but genetic heritability is increasingly understood to be an influential factor in determining a person’s risk for the disease. Coriell researchers have found a new genetic indicator of obesity risk and bolstered the understood importance of one gene’s role in obesity risk.
Superior “Bio-Ink” for 3D Printing Pioneered
Rutgers biomedical engineers have developed a “bio-ink” for 3D printed materials that could serve as scaffolds for growing human tissues to repair or replace damaged ones in the body. Their study was published in the journal Biointerphases.
‘Levitating’ proteins could help diagnose opioid abuse, other diseases
Researchers at Michigan State University’s Precision Health Program have helped develop a fascinating new method called magnetic levitation for detecting the density of proteins in the blood that could vastly improve the rate at which diseases are detected and diagnosed.
Lower Survival in Patients with High BMI and HER2+ Metastatic Breast Cancer Treated with Pertuzumab and Trastuzumab
An international team of researchers found that high BMI correlates to lower survival in patients with HER2+ metastatic breast cancer, even among patients showing initial positive response to new anti-HER2 agents pertuzumab and trastuzumab.
Mayo Clinic to sequence 100K participants to build genomic database for improved care and research in collaboration with Helix
Mayo Clinic is creating a library of genomic sequencing data on 100,000 consented Mayo Clinic participants to advance research and patient care.
Tissue-Engineering, Estrogenic Chemical–Induced Responses, and Life-Stage Physiologically Based Pharmacokinetic Modeling Featured in January 2020 Toxicological Sciences
In addition to research exploring such areas as biomarkers, nano- and neurotoxicology, and developmental and reproductive toxicology, the January 2020 issue of Toxicological Sciences features a new article category, ToxPoint, to underscore cutting-edge topics in toxicology.
ISPOR Publishes 2020 Top 10 Health Economics and Outcomes Research (HEOR) Trends Report
ISPOR—the professional society for health economics and outcomes research (HEOR), announced the publication of its 2020 Top 10 HEOR Trends report. In the report, the Society has identified the top 10 HEOR trends that will shape the field and influence healthcare over 2020 and the near future.
Mayo Clinic researchers look at post menopause as key factor in endometrial cancer
Endometrial cancer is the most common gynecological malignancy in the U.S. and the fourth most common cancer among women. In addition, endometrial cancer incidence rates are on the rise in the western world, suggesting that alterations in environmental factors such as diet, lifestyle, and the vaginal microbiome may be important drivers in its cause.
Technique shows how individual cancer cells react to drugs
A new technique reported in Science offers more detail, at the single cell level, on how large, pooled samples of various cells react to drugs or other agents. The data might reveal mode of action or the effect of genetic differences in varying responses.
Fred Hutch at ASH: Latest CAR T data – BCMA, CD19, CD20 – plus new insights on transplantation, gene therapy – and more
The 61st American Society of Hematology Annual Meeting and Exposition will take place Dec. 7–10 in Orlando, Florida
Science in Action: Wellness in the Workplace with Genetic Testing
The cost of genetic testing has steadily declined since the human genome was first mapped in 2003, allowing large employers, healthcare systems, and pension funds to adopt an upstream approach to preventative care by offering genetic testing and precision medicine as proactive wellness benefits.
Mount Sinai Announces Expanded Capability in Medical Research
New “big omics” supercomputer will speed up solutions; insights will lead to advances in a wide range of complex diseases
Researchers Find New Role for Dopamine in Gene Transcription and Cell Proliferation
A joint group of researchers at the George Washington University and the University of Pittsburgh have found that dopamine and the dopamine D2 receptor modulate expression via the Wnt/β-catenin signaling pathway. This pathway is responsible for control of cell proliferation and organ identity and is implicated in cancer, thus having broad implications for health and development of new therapeutics
IU School of Medicine awarded $36 million NIH grant for Alzheimer’s disease drug discovery center
The IU-led center is one of only two multi-institution teams in the nation selected as part of a new federal program intended to improve, diversify and reinvigorate the Alzheimer’s disease drug development pipeline.