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Development of new p38 protein inhibitors with therapeutic potential for some heart diseases

July 13, 2023 sarah JonasResearch Results

A multidisciplinary team led by Dr. Ángel R. Nebreda, Dr. María J. Macías and Dr. Modesto Orozco, all at IRB Barcelona, has developed a new type of p38 inhibitor, which preferentially impairs one of the activation pathways of this protein. In particular, these inhibitors block the self-activation (or autophosphorylation) of p38 but allow it to continue to be activated by other mechanisms.

New pathway in development of Alzheimer’s disease discovered, providing earlier target for potential therapeutics

December 4, 2020 sarah JonasResearch Results

A novel Alzheimer’s disease marker—coming early in progression of the condition—could open significant new fronts of research into possible therapies

Targeting a transporter to treat SHH medulloblastoma

March 31, 2020 sarah JonasResearch Results

Scientists at St. Jude Children’s Research Hospital have identified a novel target for a type of pediatric brain tumor.