Studies Show Subcutaneous Methylnaltrexone Provides Safe, Effective, and Rapid Relief of Opioid-Induced Constipation in Patients with Cancer

In a study of cancer patients treated with methylnaltrexone, about 50%–70% experienced relief from opioid-induced constipation within 4 hours without the use of additional treatments, compared with 15% of placebo-treated patients. In addition, more patients treated with methylnaltrexone maintained a response at 24 hours after dosing compared with patients treated with placebo.