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UrduNew insights on how subunits of the influenza virus polymerase co-evolve to ensure efficient viral RNA replication are provided by a study published October 3 in the open-access journal PLOS Pathogens by Nadia Naffakh of the Institut Pasteur, and colleagues.…
Tag: Molecular Biology
Response rate to albumin-bound paclitaxel plus gemcitabine plus cisplatin treatment among patients with advanced pancreatic cancer: A phase 1b/2 pilot clinical trial
Clinical trial demonstrates substantial patient benefit in treating late-stage pancreatic cancer one of the most aggressive of all cancers
Discovery of new source of cancer antigens may expand cancer vaccine capabilities
For more than a decade, scientist Stephen Albert Johnston and his team at Arizona State University’s Biodesign Institute have pooled their energies into an often scoffed-at, high-risk, high-reward goal in medicine: to develop a universal vaccine to prevent cancer. The…
Pioneering red light-activated anti-tumor prodrug reduces side effects
Most of the current clinical anti-tumor drugs used in chemotherapy move around in the patient’s blood after intake and are unable to pinpoint the targeted tumor. As a result, while killing the tumor cells, the healthy cells may also be…
Cracking how ‘water bears’ survive the extremes
Researchers discover that a protein in tiny tardigrades binds and forms a protective cloud against extreme survival threats such as radiation damage
Study finds rising ozone a hidden threat to corn
CHAMPAIGN, Ill. — Like atmospheric methane and carbon dioxide, ground-level ozone is on the rise. But ozone, a noxious chemical byproduct of fossil fuel combustion, has received relatively little attention as a potential threat to corn agriculture. A new study…
Earthquake in the cell
Scientists discover how a modification of the nuclear lamina maintains nuclear shape
Cloning to fight esophageal cancer
Recreating the steps to malignancy leads to faster drug discovery
Skin-Cells-Turned-to-Heart-Cells Help Unravel Genetic Underpinnings of Cardiac Function
A small genetic study, published September 30, 2019 in Nature Genetics, identified a protein linked to many genetic variants that affect heart function. Researchers are expanding the model to other organ systems and at larger scales to create a broader understanding of genes and proteins involved.
How newly found tension sensor plays integral role in aligned chromosome partitioning
A Waseda University-led research uncovered the molecular mechanism of how a particular cancer-causing oncogene could trigger an onset of acute myeloid leukemia (AML). Characterized by symptoms such as fatigue, shortness of breath, and bleeding gums, AML is a type of…
The flagellar hook: Making sense of bacterial motility
The flagellum is often cited as an example of natural design ingenuity — it is a powerful nanomachine that allows bacteria to swim effortlessly in search of food. Yet despite being a popular object of study over the last half…
Potent antibody curbs Nipah and Hendra virus attack
A monoclonal antibody prevents the virus from fusing with cell membranes to gain entry
Discovered: Possible therapeutic target for slow healing of aged muscles
New work could reveal a potential pathway for therapeutic targeting to combat muscle degeneration in the elderly
ESMO 2019: Breast and ovarian cancer drug outperforms targeted hormone therapy in some men
A drug used for breast and ovarian cancer is more effective than modern targeted hormone treatments at slowing progression and improving survival in some men with advanced prostate cancer, phase III clinical trial findings reveal. The PROfound trial compared the…
‘Relaxed’ enzymes may be at the root of Charcot-Marie-Tooth disease
LA JOLLA, CA – Treatments have been hard to pinpoint for a rare neurological disease called Charcot-Marie-Tooth (CMT), in part because so many variations of the condition exist. So far, mutations on more than 90 genes have been positively linked…
Skin-cells-turned-to-heart-cells help unravel genetic underpinnings of cardiac function
Genome-wide association studies have uncovered more than 500 genetic variants linked to heart function, everything from heart rate to irregular rhythms that can lead to stroke, heart failure or other complications. But since most of these variations fall into areas…
Cannabis study reveals how CBD offsets the psychiatric side-effects of THC
Researchers at Western University have shown for the first time the molecular mechanisms at work that cause cannabidiol, or CBD, to block the psychiatric side-effects caused by tetrahydrocannabinol (THC), the main psychoactive chemical in cannabis. It has been previously shown…
Cancer tumours form surprising connections with healthy brain cells
Healthy neurons form synapses with aggressive brain cancer cells that stimulate the growth and proliferation of brain cancer; anti-epileptic medicine can curb the dangerous communication and possibly be part of future treatment, a Norwegian study shows
Researchers make it possible for ultrasound to reveal gene expression in the body
Some of the most important tools in the toolbox of modern cell biologists are special chunks of DNA that act like spies, reporting on the cell’s function. The markers, known as reporter genes, allow researchers to get a sense for…
High-speed microscope illuminates biology at the speed of life
Developed by Columbia scientists, New SCAPE 2.0 system can serve as a critical tool to advance science and medicine
How time affects the fate of stem cells
How do temporal variations in protein concentrations affect biology? It’s a question that biologists have only recently begun to address, and the findings are increasingly showing that random temporal changes in the amount of certain proteins play a direct and…
Molecular link between chronic pain and depression revealed
Researchers at Hokkaido University have identified the brain mechanism linking chronic pain and depression in rats. Their research, which was recently published in The Journal of Neuroscience , could lead to the development of new treatments for chronic pain and…
Bacteria make pearl chains
With elegant appendages, the bacteria increase their surface area and thus improve their food intake
New fungus-derived antibiotic: relief in sight for immunocompromised people
Scientists derive a new compound from eushearilide, which can potentially take on lethal fungal and bacterial infections
Unravelling an alternative mechanism of airway mucosal immunity
A research team including Kanazawa University discover an alternative mechanism which may help control microbial infections in the airway
New mechanisms that regulate pluripotency in embryonic stem cells are discovered
A study by researchers at the Center for Cell-Based Therapy, which is supported by FAPESP, identified microRNAs involved in pluripotency maintenance and cell differentiation
DNA is held together by hydrophobic forces
Researchers at Chalmers University of Technology, Sweden, disprove the prevailing theory of how DNA binds itself. It is not, as is generally believed, hydrogen bonds which bind together the two sides of the DNA structure. Instead, water is the key.…
Researchers perform thousands of mutations to understand amyotrophic lateral sclerosis
Researchers from CRG and IBEC in Barcelona use a technique called high-throughput mutagenesis to study Amyotrophic Lateral Sclerosis (ALS), with unexpected results
Researchers perform thousands of mutations to understand amyotrophic lateral sclerosis
Researchers from CRG and IBEC in Barcelona use a technique called high-throughput mutagenesis to study Amyotrophic Lateral Sclerosis (ALS), with unexpected results
Discovery of novel cancer signaling mechanism and design of new anticancer compound
Using a newly synthesized compound and advanced immunofluorescence techniques, scientists uncover novel signaling mechanism in cancer and also propose new channel of treatment
Better samples, better science: new study explores integrity of research specimens
Effective diagnosis and treatment of disease draws on painstaking research, which often relies on biological samples. The avalanche of studies used to better understand illnesses and design effective therapies cost billions of dollars and potentially affects millions of lives. So,…
How molecular footballs burst in an x-ray laser beam
Study shows effect of x-ray flashes on sensitive biomolecules
Rethinking how cholesterol is integrated into cells
Most people have heard of “cholesterol levels” and the dangers of high blood cholesterol, which is one of the main causes of cardiovascular disease. But besides the harmful side effects of high cholesterol, cholesterol is an essential component of all…
HD microscopy in milliseconds
University researchers improve super-resolution microscopy
New factor in the development of childhood lymphoma
A study recently published in the renowned journal Blood , led by Kaan Boztug, Scientific Director of the St. Anna Children’s Cancer Research Institute, the Ludwig Boltzmann Institute for Rare and Undiagnosed Diseases (LBI-RUD), Adjunct Principal Investigator at the CeMM…
The path of breast-to-brain cancer metastasis
In 2018, breast cancer was the most common cancer in women worldwide, accounting for about a quarter of all reported cancers. One of the biggest problems with any type of cancer is metastasis; and when breast cancer metastasizes, the brain…
Did microbes assist life in colonizing land?
Comparative microbiome study enables researchers of the Kiel based CRC 1182 to gain new insights into the course of evolution
Revolutionary laser instrument receives $4.7 million boost from the National Science Foundation
Deep within the subterranean confines of Building C–the latest addition to the Biodesign Institute at Arizona State University–a pathbreaking machine is quietly taking shape. Designed to unlock some of nature’s tiniest and most fleeting mysteries, the Compact X-ray Free Electron…
Mutant live attenuated Ebola virus immunizes non-human primates
Inoculation with an Ebola virus that has mutations in a protein called VP35 does not cause disease and elicits protection in monkeys, researchers show September 17 in the journal Cell Reports . The findings suggest that the immune-evasion function of…
Study gives clues to the origin of Huntington’s disease, and a new way to find drugs
The first signs of Huntington’s, an inherited disease that slowly deteriorates bodies and minds, don’t typically surface until middle age. But new findings suggest that something in the brain might be amiss long before symptoms arise, and earlier than has…
‘Death Star’ bacterial structures that inject proteins can be tapped to deliver drugs
Not all bacteria spread diseases, many are beneficial and this strain has nanoscale syringes that deliver proteins which cause metamorphosis in marine animals, and could be modified as a novel drug delivery tool for future vaccines and cancer care
Renegade genes caught red handed
Potentially dangerous genes embedded within human DNA were once thought to be locked down by helpful DNA structures called heterochromatin. A University of Arizona researcher disputes that belief and hopes to change the paradigm even further.
Discovery concerning the nervous system overturns a previous theory
It appears that when our nervous system is developing, only the most viable neurons survive, while immature neurons are weeded out and die. This is shown in a ground-breaking discovery by researchers at Karolinska Institutet in Sweden. The results indicate…
Finding (microbial) pillars of the bioenergy community
EAST LANSING, Mich. – Stems, leaves, flowers and fruits make up the biggest chunk of potential living space for microbes in the environment, but ecologists still don’t know a lot about how the microorganisms that reside there establish and maintain…
12 early-career scientists win PROLAB awards
Twelve emerging scientists will receive grants this year from the Promoting Research Opportunities for Latin American Biochemists program, or PROLAB, to advance their research by working directly with collaborators in laboratories in the United States, Canada and Spain. Since 2012,…
Bones secrete a stress hormone
Both rodents and humans release a bone-derived hormone called osteocalcin in response to acute stress, researchers report on September 12th in the journal Cell Metabolism . This fight-or-flight pathway is distinct from others mediated by hormones released by the adrenal…
Stem cell researchers reactivate ‘back-up genes’ in the lab
Researchers in Belgium present new findings on X chromosome reactivation
Anti-aging startup launched based on breakthrough UAB research
BIRMINGHAM, Ala. – Together, hair loss prevention and anti-aging skincare represent a more than $11 billion market. Yuva Biosciences, an anti-aging startup based on technology developed at the University of Alabama at Birmingham, is harnessing its cutting-edge science to develop…
Advanced breeding paves the way for disease-resistant beans
For many people in Africa and Latin America, beans are an important staple. Historically described as “the meat of the poor”, beans are rich in protein and minerals, affordable and suitably filling. That is why they are served daily, often…
Scientists identify gene as master regulator in schizophrenia
CHOP researchers: Finding may offer a key target for future treatments