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UrduAs many expectant mothers know, getting enough folate is key to avoiding neural tube defects in the baby during pregnancy. But for the individuals who carry certain genetic variants, dealing with folate deficiency can be a life-long struggle which can…
Tag: Molecular Biology
Beckman neuroscientists uncover neuronal circuitry controlling auditory sensory perception
A team of neuroscientists at the Beckman Institute for Advanced Science and Technology discovered a new neuronal circuit that may help control which sensory information is relayed to the auditory cortex
Study finds structural changes in the SARS-CoV-2 Alpha and Beta variants
Changes to the ‘spike’ protein explain Alpha’s faster spread, and how the Beta variant evades immune responses, suggesting the need for a booster with an updated vaccine
Kiwi disease study finds closely related bacterial strains display different behaviors
Over the last decade, severe outbreaks of bacterial canker have caused huge economic losses for kiwi growers, especially in Italy, New Zealand, and China, which are among the largest producers. Bacterial canker is caused by the bacterial pathogen Pseudomonas syringae…
Novel risk score for predicting blood cancer relapse
Medical researchers in China develop a new risk score to predict relapse of leukemia
Ubiquitination primes cell for recovery from heat stress
Not all stresses are created equal, according to a pair of new studies, which shows that distinct ubiquitination patterns underlie cell recovery following different environmental stressors. Eukaryotic cells respond to environmental stressors – such as temperature extremes, exposure to toxins…
How Cells “Read” Artificial Ingredients Tossed into Genetic Recipe
UC San Diego School of Medicine researchers discovered that the enzyme RNA polymerase II recognizes and transcribes artificially added base pairs in genetic code, a new insight that could help advance the development of new vaccines and medicines.
Study identifies trigger for ‘head-to-tail’ axis development in human embryo
Scientists have identified key molecular events in the developing human embryo between days 7 and 14 – one of the most mysterious, yet critical, stages of our development. The second week of gestation represents a critical stage of embryo development,…
Close-up look at brain uptake of omega-3
SINGAPORE, 17 June 2021 – New details on the structure and function of a transport protein could help researchers develop drugs for neurological diseases that are better able to cross the blood-brain barrier. The findings were published in the journal…
Foresight diagnostics to show vision of the new standard of lymphoma MRD detection at ICML
AURORA, COLORADO, June 16, 2021 — Foresight Diagnostics, the emerging leader in blood-based lymphoma disease monitoring, announced today that clinical performance of its minimal residual disease (MRD) detection platform in diffuse large B-cell lymphoma (DLBCL) will be presented at the…
Beyond mere blueprints: Variable gene expression patterns and type 1 diabetes
A recently published review explores the role of epigenetic factors in the development and progression of type 1 diabetes
Algorithm uses mass spectrometry data to predict identity of molecules
New method saves time, money in developing new drugs
CNIO researchers find molecular switch that allows organisms to adapt to fasting conditions
The mechanism involved is an ancient molecular pathway we share with yeasts; despite its relevance, very little was known about its role in metabolism
Convergent mechanism of aging discovered
Fundamental signaling pathway is crucial for longevity
Fossil research shows woodlice cousins roamed Ireland 360 million years ago
New techniques used to recreate the image of the Oxyuropoda – the cousin of the garden woodlice
Study reveals recipe for even more powerful COVID-19 vaccines
NEIDL, Broad Institute scientists say next-generation vaccines could stimulate another arm of the immune system, imparting better protection against coronavirus variants
Omega-3s may hold key to unlocking blood-brain barrier
NEW YORK, NY (June 16, 2021)–Spectacular images of a molecule that shuttles omega-3 fatty acids into the brain may open a doorway for delivering neurological therapeutics to the brain. “We’ve managed to obtain a three-dimensional structure of the transporter protein…
The ISSCR 2021 Annual Meeting starts 21 June
Six days of exceptional stem cell science
Like your olives bitter? Molecular breeding can make them even better!
Scientists from China assembled a high-quality genome of a European olive species and identified genes of economic importance
Harnessing the power of nature through productive microbial consortia in biotechnology
The deliberate control of complex microbiomes is notoriously difficult and current approaches are often guided by simple trial-and-error. The new Horizon 2020 project PROMICON – Harnessing the power of nature through PROductive MIcrobial CONsortia in biotechnology – measure, model, master…
Graphene ‘camera’ captures real-time electrical activity of beating heart
Graphene sheet acts like video camera to record fleeting electrical signals of neurons, cardiac cells
About the beginning of life, bacteria in the gut and collective intelligence in bees
News from the life sciences
From symmetry to asymmetry: The two sides of life
Researchers at Osaka University use innovative imaging techniques to dynamically demonstrate that symmetric, collective alignment of cell nuclei influences left-right asymmetric development in the midgut of the fruit fly embryo
Fungal spores from 250-year-old collections given new lease of life
Echoing through history by reviving fungal specimens originally preserved and described a flabbergasting quarter of a millenium ago by the “Father of Modern Taxonomy” Carl Linnaeus, this study highlights the untapped potential of museum collections in modern research programmes. The…
CNIO researchers discover that a protein that facilitates DNA repair may potentiate chemotherapy
The PrimPol protein helps the cell to survive the damage caused by chemotherapy; the researchers want to make tumor cells more sensitive to cancer treatments by repressing PrimPol
Alzheimer disease research results over-hyped if science papers omit mice from the title
Scientists call for accurate reporting of animal studies to avoid misleading the public with exaggerated news headlines
Scientists explain the crucial role of motor proteins in cell division
Molecular biologists from the Croatian Ru?er Boškovi? Institute have answered one of the long-standing open questions in cell biology!
Accomplished University of Ottawa professors earn Canada Research Chairs
The University of Ottawa has been awarded four new Canada Research Chairs
A new model of Alzheimer’s progression
Alzheimer’s disease is the most common form of dementia and is characterized by neurodegeneration in regions of the brain involved in memory and learning. Amyloid beta and tau are two toxic proteins that build up in disease and cause eventual…
New health benefits of red seaweeds unveiled
Red seaweeds have been prevalent in the diets of Asian communities for thousands of years. In a new study, published in Marine Drugs , researchers have shown how these algae confer health benefits. “In the past, people have wondered why…
Hair follicles heal blisters at personal cost
A team of scientists has shown that the healing of skin blisters is driven by hair follicle stem cells, which delay their own development in the process. The healing process of the tissues in the human body is particularly well-studied…
Toward the first drug to treat a rare, lethal liver cancer
Treatment options for a deadly liver cancer, fibrolamellar carcinoma, are severely lacking. Drugs that work on other liver cancers are not effective, and although progress has been made in identifying the specific genes involved in driving the growth of fibrolamellar…
RNA: A new method to discover its high-resolution structure
New SISSA research combines experimental data and molecular dynamics simulations to study biomolecules in their natural environment; the work has been published in Nucleic Acids Research
Are we genetically ‘grounded’?
Hebrew University identifies molecular factors that enable birds to fly, but keep the rest of us on terra firma
NYUAD study offers new insight into one of the mysteries of natural immunity to malaria
Researchers compared metabolic responses to human malaria in children of different populations
Pinpointing how cancer cells turn aggressive
Penn scientists have developed a new method for tracing the lineage and gene expression patterns of metastatic cancer at the single-cell level
Scientists uncover the mysteries of how viruses evolve
Scientists uncover the mysteries of how viruses evolve
Ion and lipid transporters specialize for their niche
Cell viability require that a variety of functions at the cell membrane are maintained properly. P-type ATPases translocate substrates across the membrane, and they have evolved into different types taking care of specific substrates within a diverse range. Now, key…
A new mechanism behind continuous stem cell activity in plants
Family rivalry between transcription factors
Trapping DNA damage
Untangling the proteins that trigger some cancerous tumors
‘Bad fat’ suppresses killer T cells from attacking cancer
Salk researchers identify how tumors cause immune cells to lose their ability to fight cancer, opening new avenues for therapies
Research establishes safe water thresholds for antimicrobials, to help mitigate resistance
Researchers have made progress towards a G7 commitment to establish safe standards for the release of antimicrobials into the environment, by developing a new framework that establishes safe thresholds
How do plants balance microbial friends and foes?
Plants are constantly exposed to microbes: pathogens that cause disease, commensals that cause no harm or benefit, and mutualists that promote plant growth or help fend off pathogens. For example, most land plants can form positive relationships with arbuscular mycorrhizal…
CWRU researcher secures $1.2M to develop MS diagnostic tests
CLEVELAND–Case Western Reserve University researcher Farren Briggs was awarded $1.2 million over three years from the National Institute of Neurological Disorders and Stroke (NINDS) at the National Institutes of Health to identify biomarkers to improve the diagnoses of multiple sclerosis…
How cells measure themselves
Ever since scientists discovered cells under the microscope more than 350 years ago, they have noted that each type of cell has a characteristic size. From tiny bacteria to inches-long neurons, size matters for how cells work. The question of…
Forget me not: Novel target shows promise in treating Alzheimer’s and related dementias
A novel tau protein conformation, cis P-tau, is a toxic early driver of Alzheimer’s disease and related dementias and silencing of this protein through immunotherapy ameliorates dementia symptoms in preclinical models
New study gives clue to the cause, and possible treatment of Parkinson’s Disease
Zebrafish model research reveals clues about molecular triggers of Parkinson’s Disease
New defence against superbugs
Taking fish oil may reduce antibiotic resistance
Scientists use public databases to leap over scourge of publication bias
Scientists have leapt over the emerging problem of publication bias within genetic research by performing a meta-analysis of publicly available databases of ‘transcriptomes’, or the full range of messenger RNA molecules produced by an organism. Researchers from Hiroshima University applied…
Study shows new links between high fat diets and colon cancer
For decades, physicians and dieticians have urged people to limit their intake of high fat foods, citing links to poor health outcomes and some of the leading causes of death in the U.S., such as diabetes, heart disease and cancer.…