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UrduMass spectrometry has helped identify potential biomarkers and new treatment targets for Huntington’s disease report scientists in the Journal of Huntington’s Disease who reviewed 20 years of published studies
Tag: Molecular Biology
The path(way) less traveled in DNA double-strand break repair
Researchers from Osaka University find that protein phosphatase 1 helps protect the ends of double-strand DNA breaks to promote their repair through the non-homologous end joining pathway
Selective, Toxin-Bearing Antibodies Could Help Treat Liver Fibrosis
UC San Diego researchers discovered that immunotoxins targeting the protein mesothelin prevent liver cells from producing collagen, a precursor to fibrosis and cirrhosis, in mouse models of human disease.
Scientists blueprint bacterial enzyme believed to “stealthily” suppress immune response
Scientists have produced the first fine-detail molecular blueprints of a bacterial enzyme known as Lit, which is suspected to play a “stealthy” role in the progression of infection by reducing the immune response. Blueprints such as these allow drug designers…
First actionable clock that predicts immunological health and chronic diseases of aging
Research highlights the critical role of the immune system in the aging process
Hijacked immune activator promotes growth and spread of colorectal cancer
Through a complex, self-reinforcing feedback mechanism, colorectal cancer cells make room for their own expansion by driving surrounding healthy intestinal cells to death – while simultaneously fueling their own growth. This feedback loop is driven by an activator of the…
Symbionts sans frontieres: Bacterial partners travel the world
Some bacterial symbionts in travel the globe and are true cosmopolitans
Sensing “junk” RNA after chemotherapy enhances blood regeneration
Hematopoietic stem cells take advantage of RNA from pathogenic remnants integrated in the genome to replenish the blood system
$1M NIGMS grant gives students at Lewis Katz School of Medicine chance at early success
(Philadelphia, PA) – Rapid evolution in the field of biomedical research demands well-trained scientists. Adapting biomedical research training programs to keep up with the increasingly complex and interdisciplinary nature of the field, however, presents complex challenges for higher-education institutions. The…
Brain injury lab receives additional federal funding to boost research
UC Riverside postdoc and graduate students are recipients of new awards
New genetic driver of autism and other developmental disorders identified
A research group including Kobe University’s Professor TAKUMI Toru (also a Senior Visiting Scientist at RIKEN Center for Biosystems Dynamics Research) and Assistant Professor TAMADA Kota, both of the Physiology Division in the Graduate School of Medicine, has revealed a…
NIST uses method to understand the molecular underpinnings of a disease affecting corals
Coral reefs are a favorite spot for scuba divers and are among the world’s most diverse ecosystems. For example, the Hawaiian coral reefs, known as the “rainforests of the sea,” host over 7,000 species of marine animals, fishes, birds and…
Neonatal meningitis: the immaturity of microbiota and epithelial barriers implicated
Meningitis is associated with high mortality and frequently causes severe sequelae. Newborn infants are particularly susceptible to this type of infection; they develop meningitis 30 times more often than the general population. Group B streptococcus (GBS) bacteria are the most…
Computer-assisted biology: Decoding noisy data to predict cell growth
Tokyo, Japan – Scientists from The University of Tokyo Institute of Industrial Science have designed a machine learning algorithm to predict the size of an individual cell as it grows and divides. By using an artificial neural network that does…
Discovery of a mechanism for efficient autophagosome formation
Revealing the molecular role of the most famous autophagy factor
Newborn screening for epilepsy in sight through the discovery of novel disease biomarkers
The door has finally opened on screening newborn babies for pyridoxine-dependent epilepsy (PDE), a severe inherited metabolic disorder. This screening promises to enable better and earlier treatment of the disease. To identify new biomarkers that can be used in the…
STFC technology drives more efficient cryoEM imaging
New 100 keV CryoEM camera launching with collaborations from STFC, RFI and Quantum Detectors
More ancestral enzyme
Molecular evolution of enzyme beyond recruit hypothesis
Protein crop’s potential unlocked by deciphering anti-nutrient biosynthesis
Faba beans are an excellent source of food protein, but about 4% of the world’s population are afflicted by favism, which renders them sensitive to the faba bean anti-nutrients vicine and convicine. Now, an international research team has identified the…
Large genomic analysis highlights COVID-19 risk factors
An international collaboration uncovers several genetic markers associated with SARS-CoV-2 infection and COVID-19 severity
Precision medicine helps identify “at-risk rapid decliners” in early-stage kidney disease
A novel therapeutic may halt rapid kidney function in some type 1 diabetic kidney disease patients.
Research reveals structure of nanomachine that assembles a cell’s energy control system
Sussex researchers have determined the structure of a tiny multi-protein biological machine, furthering our understanding of human cells and helping to enhance research into cancer, neurodegeneration and other illnesses
CNIO researchers help to decipher the structure of the large molecular machine that activates mTOR
“As our understanding of the mechanisms that control mTOR grows, new possibilities are opening up to interfere with these processes for therapeutic purposes,” says Óscar Llorca, co-author of the study
Mount Sinai research reveals how Ebola virus manages to evade the body’s immune defenses
New York, NY (July 6, 2021) – Mount Sinai researchers have uncovered the complex cellular mechanisms of Ebola virus, which could help explain its severe toll on humans and identify potential pathways to treatment and prevention. In a study published…
New insights into Salmonella’s survival strategies
EMBL scientists shed light on how Salmonella hijacks the machinery of its host cell to promote its own growth and reproduction
Protein’s ‘silent code’ affects how cells move
A University of Pennsylvania-led study shows how, despite having nearly identical amino acid sequences, two forms of the protein actin differ in function due their distinct nucleotide sequences
Researchers discover way to improve immune response
Melbourne researchers have identified a way to improve the immune response in the face of severe viral infections. It is widely known that severe viral infections and cancer cause impairments to the immune system, including to T cells, a process…
New signaling pathway could shed light on damage repair during brain injury
The study has uncovered a signaling pathway that causes neural cells to enter divisions after damage
Acid sensor discovered in plants
Climate change is causing increased flooding and prolonged waterlogging in northern Europe, but also in many other parts of the world. This can damage meadow grasses, field crops or other plants – their leaves die, the roots rot. The damage…
SARS-CoV-2 encoded miRNA is a biomarker for stratification of severe patients
In a retrospective, multi-centre cohort study conducted by researchers from Nanjing University, Huazhong University of Science and Technology, Jinling Hospital and the Second Hospital of Nanjing, a microRNA-like small RNA encoded by SARS-CoV-2 was identified in the serum of COVID-19…
Epsilon variant mutations contribute to COVID immune evasion
Studies reveal unprecedented mechanism behind loss of antibody neutralization against this pandemic coronavirus variant of concern
New broadly applicable tool provides insight into fungicide resistance
Succinate dehydrogenase inhibitors (SDHIs) are a class of fungicides widely used to control many fungal diseases of crops. The relationship between SDHIs and fungi can be compared to finding the right key for the right lock. However, fungi are adaptable…
NYU Abu Dhabi researchers unlock secrets behind liver regrowth and regenerative medicine
New insight into the liver’s unique ability to regenerate holds promise for developing treatments for the lung, heart, and other organs that currently must be replaced by transplants
Memory making involves extensive DNA breaking
The urgency to remember a dangerous experience requires the brain to make a series of potentially dangerous moves: Neurons and other brain cells snap open their DNA in numerous locations–more than previously realized, according to a new study–to provide quick…
Lipidomics research provides clues for drug resistance in schizophrenia
Researchers from Skoltech and the Mental Health Research Center have found 22 lipids in the blood plasma of people with schizophrenia that were associated with lower symptom improvement over time during treatment. These can help track resistance to medication that…
Making sense of antisense gene silencing
Researchers from Tokyo Medical and Dental University (TMDU) find proteins that bind to and regulate tocopherol-conjugated heteroduplex oligonucleotides during gene silencing Tokyo, Japan – Gene silencing therapies are used to interfere with, or “silence”, the expression of genes that are…
Study shows the mechanism how loss of de-N-glycosylation enzyme causes ill effect
Peptide: N-glycanase (NGLY1) is an evolutionarily conserved enzyme for removing N-linked glycans (N-glycans) from glycoproteins and is involved in proteostasis of N-glycoproteins in the cytosol. In 2012, a rare genetic disorder called NGLY1 deficiency was discovered by an exome analysis.…
More filling? Tastes great? How flies, and maybe people, choose their food
Flies have discriminating taste. Like a gourmet perusing a menu, they spend much of their time seeking sweet nutritious calories and avoiding bitter, potentially toxic food. But what happens in their brains when they make these food choices? Yale researchers…
Potential Drug Target for Difficult-To-Treat Breast Cancer: RNA-Binding Proteins
UC San Diego studies using human cell lines and tumors grown in mice provide early evidence that inhibiting RNA-binding proteins, a previously overlooked family of molecules, might provide a new approach for treating some cancers.
Uncovering the genetic mechanism behind Rett syndrome
Dysfunction in key gene causes neural stem cells to produce more astrocytes than neurons
How ethane-consuming archaea pick up their favorite dish
Scientists of Bremen sucessfully decoded the structure of the enzyme responsible for ethane fixation
Three-in-one approach boosts the silencing power of CRISPR
A newly developed CRISPR-Cas9-based tool carries out efficient and long-term gene silencing by epigenetic editing
Inside the lungs, a new hope for protection against flu damage
New experimental data pinpoints a molecular component responsible for modulating the damage the flu can wreck on the lungs
NYUAD study maps nanobody structure, leading to new ways to potentially fight diseases
Fast facts: Nanobodies have been shown to inhibit the dysfunction of key proteins involved with various diseases such as rheumatoid arthritis, osteoarthritis, psoriasis, B-cell lymphoma, and breast cancer Understanding the structure of a nanobody helps to better understand its disease-fighting…
UMass Amherst research pinpoints role of dopamine in songbird’s brain plasticity
Neurotransmitter shown to be a key driver in sensory processing
Manufacturing the core engine of cell division
By modelling the kinetochore from scratch, Max Planck Institute’s researchers get a step closer to creating artificial chromosomes
Introducing ‘sci-Space,’ a new method for embryo-scale, single-cell spatial transcriptomics
Researchers introduce “sci-Space,” a new approach to spatial transcriptomics that can retain single-cell resolution and spatial heterogeneity at scales much larger than previous methods. They used their approach to build single-cell atlases of whole sections of mouse embryos at 14…
FAPESP webinar will discuss how SARS-COV-2 affects the human brain
Renowned scientists will focus on COVID’s impact on the human brain addressing molecular mechanisms from both cellular and organismal viewpoints
SARS-CoV-2 replication targets nasal ciliated cells early in COVID-19 infection
The establishment of nasal mucosal immunity against SARS-CoV-2 through a nasal vaccine could be the most efficient way to combat COVID-19 infection
G-quadruplex-forming DNA molecules enhance enzymatic activity of myoglobin
A collaboration led by Distinguished Professor Dr. Kazunori Ikebukuro from Tokyo University of Agriculture and Technology (TUAT), Japan, discovered that G-quadruplex (G4)-forming DNA binds myoglobin through a parallel-type G4 structure. Through the G4 binding, the enzymatic activity of myoglobin increases…