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UrduIn a new article published in the journal Immunity, Moffitt Cancer Center researchers show that TIM-3 inhibits the STING signaling pathway in dendritic cells, thereby blocking their ability to elicit an immune response.
Tag: Moffitt Cancer Center
New Blueprint of Brain Connections Reveals Extensive Reach of Central Regulator
In a new article published in Nature Communications, Moffitt Cancer Center researchers show how the location of the tumor and spatial constraints put on it by the surrounding tissue architecture impact genetic heterogeneity of tumors.
A World without Cervical Cancer: Preventive Medicine publishes special issue to further global efforts to eliminate deadly disease
Cervical cancer is a serious global health threat which kills more than 300,000 women every year. Recognizing this urgent public health issue, the editorial team of Preventive Medicine is publishing a special issue titled “From Science to Action to Impact: Eliminating Cervical Cancer,” which outlines the required courses of action to eliminate cervical cancer. Dr. Anna Giuliano and Dr. Linda Niccolai, two giants in the field of cervical cancer prevention research, served as guest editors for the issue.
Moffitt Researchers Show Sequential Treatment with Immunotherapy and Checkpoint Inhibitors Prolongs Anti-Tumor Activity
In a new article published in Cancer Immunology Research, the Moffitt team shows that sequential administration of immunotherapy followed by targeted therapy prolongs anti-tumor responses in preclinical models and may be a potential treatment option for patients with advanced melanoma.
Lung Cancer Cells Have Differential Signaling Responses to KRAS Inhibitor Treatment with Important Implications for Emerging Clinical Trials
In a new article published in Clinical Cancer Research, Moffitt Cancer Center researchers show that various subtypes of lung cancer cells activate different signaling pathways in response to KRASG12C inhibitor treatment. These results may help identify potential combination therapy approaches and guide treatment decisions for lung cancer patients in the future.
Moffitt Researchers Use Mathematical Modeling to Identify Factors that Determine Adaptive Therapy Success
In a new article featured on this month’s cover of Cancer Research, Moffitt Cancer Center researchers, in collaboration with Oxford University, report results from their study using mathematical modeling to show that cell turnover impacts drug resistance and is an important factor that governs the success of adaptive therapy.
Moffitt Researchers Discover Mechanism that Regulates Anti-Tumor Activity of Immune Cells in Ovarian Cancer
In a new article published in Nature, Moffitt Cancer Center researchers demonstrate why some ovarian cancer patients evolve better than others and suggest possible approaches to improve patient outcomes.
Moffitt Researchers Identify Why CAR T Therapy May Fail in Some Lymphoma Patients
In a new study published in Blood, the official journal of the American Society of Hematology, Moffitt researchers show that immune dysregulation can directly affect the efficacy of CAR T therapy in patients with diffuse large B-cell lymphoma.
Investigational Combo Therapy Shows Benefit for TP53 Mutant MDS and Acute Myeloid Leukemia Patients
Moffitt Cancer Center is leading a national, multicenter clinical trial investigating a new therapy option for this group of patients. It builds upon the standard of care therapy, combining eprenetapopt (APR-246) with the chemotherapy azacitidine. Results of the phase 1b/2 trial to determine the safety, recommended dose and efficacy of the combination therapy were published in the Journal of Clinical Oncology.
Spontaneous Cell Fusions Amplify Genetic Diversity Within Tumors, Moffitt Researchers Say
mechanism available to pathogenic microbes – the ability to exchange and recombine genetic material between different cells. However, in a new article published in Nature Ecology & Evolution, Moffitt Cancer Center researchers demonstrate that this belief is wrong and that cancer cells are capable of exchanging and recombining their genetic material with each other through a mechanism mediated by cell fusions.
Moffitt Researchers Identify How Cancer Cells Adapt to Survive Harsh Tumor Microenvironments
To better understand the conditions that select for the Warburg Effect and the mechanisms where cells can express this metabolic adaptation, Moffitt researchers subjected nonmalignant cells to the harsh tumor microenvironment that is present during early carcinogenesis, known as ductal carcinoma in situ. In a new research article published in the Proceedings of the National Academy of Sciences, the Moffitt team shows that these conditions select for cells to express a Warburg Effect.
Moffitt Researchers Discover Biochemical Pathway That Protects Cells from Ferroptosis Cell Death
In an article published in Cell Metabolism, Moffitt Cancer Center researchers report on a newly discovered biochemical pathway that protects cells from a type of cell death called ferroptosis.
Study Identifies Exposure to Common Food-Borne Pathogen Linked to Rare Brain Cancer
A new study suggests a link between toxoplasma gondii (T. gondii) infection and the risk of glioma, a type of brain cancer, in adults. The report, appearing in the International Journal of Cancer, finds that people who have glioma are more likely to have antibodies to T. gondii (indicating that they have had a previous infection) than a similar group that was cancer free.
Moffitt Researchers Discover Potential New Drug Target to Treat Cutaneous T Cell Lymphoma
In order to improve their understanding of how CTCL develops in hopes of developing new therapies, a team of Moffitt immunologists and hematologists conducted a series of studies. In an article published in The Journal of Clinical Investigation, they demonstrate that decreased expression of the protein SATB1 contributes to CTCL development and that drugs that cause SATB1 to become re-expressed may be potential treatment options for this disease.
Moffitt Researchers Identify Genomic and Immune Indicators That Predict Lethal Outcomes in High-Grade Prostate Cancer
Moffitt Cancer Center researchers conducted studies to determine if genomic heterogeneity in tumors from grade 4/5 prostate cancer patients can be exploited to identify patient subsets that are at higher risk for lethal outcomes and that may benefit from targeted treatment strategies. Their results were published in the journal European Urology.
Moffitt Program Bringing Patients, Scientists Together Infuses New Meaning into Research
Because they spend most of their time in their labs, basic science researchers rarely get to meet the patients who benefit most from their work. A group at Moffitt Cancer Center decided to change that, and with the creation of the Patient Researcher Forum, the cancer center has found a way for researchers and patients to engage with each other.
Moffitt Researchers Create Chimeric Antigen Receptor Mutations to Enhance CAR T Cell Activity and Survival
Moffitt Cancer Center researchers are working to improve CAR T responses and make those responses more long-lasting for patients. In a new article published in Cancer Immunology Research, the team shares its findings, which show alterations to a specific domain of the chimeric antigen receptor enhances CAR T-cell activity and survival.
Genomic Differences May Be Key to Overcoming Prostate Cancer Disparities Among African American Men
In a new article published in Clinical Cancer Research, Moffitt Cancer Center researchers describes the immune-oncologic differences in prostate cancer tumors of African American men and how those variations may be exploited to develop more personalized treatment approaches for this population.
Moffitt Researchers Develop Tool to Better Predict Treatment Course for Lung Cancer Patients
In a new article published in Nature Communications, Moffitt Cancer Center researcher demonstrate how a deep learning model using positron emission tomography/computerized tomography radiomics can identify which non-small cell lung cancer patients may be sensitive to tyrosine kinase inhibitor treatment and those who would benefit from immune checkpoint inhibitor therapy.
Moffitt Researchers Discover Specific Molecules that Promote Cancer Progression
In a new article published in the journal Nature Communications, Moffitt Cancer Center researchers describe how the protein TAp63 controls levels of RNA molecules, which subsequently connects the activities of p53 and AKT to promote disease progression.
Moffitt Researchers Identify Driver of Further Metastasis in BRAF Inhibitor Resistant Melanoma
In a new article published in the Journal of Investigative Dermatology, Moffitt researchers identify erythropoietin-producing hepatocellular receptor A2 (EphA2) as a driver of metastasis and BRAF-MEK inhibitor resistance in melanoma.
Moffitt Researchers Identify Factors to Predict Severe Toxicities in CAR T Patients
In a new study published in Clinical Cancer Research, Moffitt Cancer Center researchers identify possible factors that could help physicians know if patients are at higher risk for severe adverse events before they receive CAR T therapy.
Moffitt Researchers Identify Protein that Causes Epithelial Cancers to Spread
In a new article published in the July issue of Cancer Research, Elsa Flores, Ph.D., and her team discovered a key protein that oscillates its expression through microRNA regulation to facilitate cancer spread to distant organs. This protein is ∆Np63, a member of the p53 family of tumor suppressor genes.
Moffitt Researchers Develop Tool to Detect Patients at High Risk for Poor Lung Cancer Outcomes
In a new study published in Nature Scientific Reports, Moffitt Cancer Center researchers have shown how the use of radiomics can improve lung cancer screening by identifying early stage lung cancer patients who may be at high risk for poorer outcomes, and therefore require aggressive follow-up and/or adjuvant therapy.
Moffitt Researchers Develop Model to Predict Prostate Cancer Aggressiveness
Researchers in the Center of Excellence for Evolutionary Therapy at Moffitt Cancer Center want to better understand what is happening in the tumor microenvironment to drive prostate cancer to become aggressive and grow rapidly. In a new article published in Nature Ecology & Evolution, the research team provides a closer look at a multiscale mathematical model they developed to analyze integrated biologic and pathologic data to determine tumor aggressiveness.
Moffitt Cancer Center Study Suggests More Could Benefit from CAR T-Cell Therapy
Moffitt Cancer Center organized a consortium of 16 cancer treatment facilities across the U.S. that offer Yescarta as a standard-of-care therapy for patients with relapsed/refractory large B cell lymphoma. They wanted to determine if the safety and effectiveness seen in the ZUMA-1 clinical trial were similar for patients treated with the now commercially available CAR T therapy. Their findings were published in the Journal of Clinical Oncology.
Moffitt Researchers Identify Molecular Pathway That Controls Immunosuppression in Tumors
In a new article published in the journal Immunity, Moffitt Cancer Center researchers reveas how protein-signaling pathways associated with cellular stress processes turn myeloid cells into tumor-promoting players. They also suggest that targeting the PERK protein may be an effective therapeutic approach to reactivate the immune system and boost the effectiveness of immunotherapy.
Moffitt Researchers Develop Mathematical Model to Predict Patient Outcomes to Adaptive Prostate Cancer Therapy
In an article published in Nature Communications, Moffitt Cancer Center researchers provide a closer look at a mathematical model and data showing that individual patient alterations in the prostate-specific antigen (PSA) biomarker early in cancer treatment can predict outcomes to later treatment cycles of adaptive therapy.
Moffitt Researchers Identify Novel Therapeutic Targets in Cutaneous Squamous Cell Carcinoma
Researchers at Moffitt Cancer Center want to devise better therapeutic strategies for patients with cutaneous squamous cell carcinoma (cuSCC) by improving their understanding of how the disease develops. In a new article published online ahead of print in the journal Cancer Research, Moffitt scientists report on their identification of potential therapeutic targets for cuSCC.
Moffitt Researchers Discover Novel Role of Specific Histone Deacetylase in Non-Small Cell Lung Cancer
Researchers at Moffitt Cancer Center are trying to identify alternative strategies to treat non-small cell lung cancer. (NSCLC) In a new article published online in Scientific Reports, they highlight how targeting the histone deacetylase HDAC11 may be a novel therapeutic strategy for NSCLC.
Moffitt Researchers Say Multiple Drug Adaptive Therapy is Possible
In a new article published online ahead of print in Cancer Research, members of Moffitt’s Center of Excellence for Evolutionary Therapy present a case study of an adaptive treatment approach based on evolutionary principles in prostate cancer and suggest that these strategies may provide a path toward improved multidrug adaptive therapies.
Moffitt’s Top Blood Cancer Research Highlighted at the American Society of Hematology Annual Meeting
Moffitt Cancer Center, a leader in the clinical care and research of blood malignancies, will present its top clinical research at the 61st American Society of Hematology Annual Meeting, Dec. 7-10 at the Orange County Convention Center in Orlando, Fla.
Moffitt Researchers Identify a Mechanism Controlling Tumor Cell Recognition by Immune Cells
Immunotherapy has become a standard treatment approach for several types of cancer, including melanoma. However, tumors can escape immune cell detection even with the use of immunotherapies. In a new study published in Cancer Immunology Research, Moffitt Cancer Center researchers, in collaboration with the University of Miami’s Miller School of Medicine, describe a cellular mechanism that controls tumor cell recognition by immune cells.
New Drug Combination Shows Promising Activity in Non-Small Cell Lung Cancer Patients
Patients with non-small cell lung cancer (NSCLC) now have more improved treatment options compared to standard of care with the addition of several new agents called immune-checkpoint inhibitors (ICI). Despite these changes, many patients still develop progressive disease after ICI treatment. In a new study published in Clinical Cancer Research, Moffitt Cancer Center researchers describe promising results from an early clinical trial that may offer patients who progress after ICI an additional treatment option.
Moffitt Researchers Develop Model to Personalize Radiation Treatment for Breast Cancer Patients
A personalized approach to cancer treatment has become more common over the last several decades, with numerous targeted drugs approved to treat particular tumor types with specific mutations or patterns. However, this same personalized strategy has not translated to radiation therapy, and a one-size-fits-all approach for most patients is still common practice. Moffitt Cancer Center researchers hope to change this mindset for radiation treatment with the development of a genomically-based model that can optimize and personalize a radiation dose to match an individual patient’s needs.