news, journals and articles from all over the world.
UC San Diego Health will be a test site for a third, major Phase III clinical trial to assess a vaccine candidate for the novel coronavirus that causes COVID-19. Sponsored by Janssen Pharmaceuticals, the trial will recruit up to 60,000 participants at sites in the United States and worldwide.
Researchers at University of California San Diego School of Medicine, in collaboration with local partners, have been awarded a $5 million grant from the National Institutes of Health (NIH) to implement a program of widespread testing for COVID-19 in San Ysidro, focused on pregnant women and children.
Researchers at UC San Diego report that while Kawasaki disease occurs in clusters, the traits, and thus the triggers of the inflammatory disease vary among clusters.
Analyzing anonymized patient medical records, UC San Diego researchers discovered that cholesterol-lowering statins reduced risk of severe COVID-19 infection, while lab experiments uncovered a cellular mechanism that helps explain why.
During the lockdown with COVID-19 restrictions in place, an interactive gaming room built to accelerate stroke patient recovery in The Johns Hopkins Hospital wasn’t getting much use. The therapists and neurologists running the gaming room decided to make the room available to staff treating COVID-19 patients to allow them to decompress.
Using sensitive parameters to assess cardiac function, researchers at Children’s Hospital of Philadelphia (CHOP) have found that cardiac involvement in multisystem inflammatory syndrome in children (MIS-C) differs from Kawasaki disease (KD) and is associated with myocardial injury. The findings were published recently in the Journal of the American College of Cardiology.
A consortium of 12 health systems, led by UC San Diego Health, introduces COVID19questions.org, a site where clinicians, researchers, patients and the general public are invited to submit questions that could be answered by COVID-19 patient medical record data from 200+ hospitals.
The American Academy of Dermatology has named board-certified dermatologist Esther Freeman, MD, PhD, DTM&H, FAAD, a Patient Care Hero for developing an international registry that tracks the many ways COVID-19 manifests itself through the skin.
Penn study finds patients with low pulse oximetry readings or fever were more than three times as likely to require hospitalization after their initial discharge as compared to other COVID patients
Today, California approved a new voluntary pilot program that uses Apple and Google smartphone technology to help rapidly control COVID-19 outbreaks. The program will launch on the campus of UC San Diego for any students and employees who opt in.
Front-line Worker Story: Ebony Hunter — Teamwork Will Get Us Through
It seems there will never be enough “thank-you’s” for the incredible doctors, nurses, technicians and support staff members who are working around the clock to help patients who have COVID-19, the dangerous coronavirus disease. Their dedication, determination and spirit enable Johns Hopkins to deliver the promise of medicine.
As the COVID-19 pandemic continues to impact the world in sometimes devastating and unexpected ways, a more well-known illness — the flu — will make its annual debut in the coming weeks. Flu activity tends to increase in October and can run as late as May. It’s too soon to tell how flu season will definitively affect the current pandemic. However, Johns Hopkins Medicine experts say prevention will be key in reducing the spread of both illnesses, including getting an annual flu vaccine, washing hands, wearing a face mask or covering, and maintaining proper physical distancing.
Significance of paperThis paper authored by a group of scientists from the Center for Global Infectious Disease Research at Seattle Children’s Research Institute presents a promising concept for disrupting the life cycle of a virus using synthetic lethality. When viruses infect…
UC San Diego Health is the first hospital in San Diego and only health care system in Southern California to transplant a liver from a donor with Human Immunodeficiency Virus (HIV) into an HIV-positive recipient. The surgery is part of a national clinical trial.
UC San Diego Health will be part of the Phase III national AstraZeneca clinical trial that will recruit up to 30,000 participants at multiple sites across the country to assess the safety and efficacy of a vaccine to prevent COVID-19.
Mount Sinai will serve as the official medical services provider for the eighth consecutive year at the US Open
In a commentary, researchers demonstrate the stark differences in public health strategies from two democratic republics: South Korea and the United States, which have led to alarming differences in cases and deaths from COVID-19. After adjusting for the 6.5 fold differences in populations, the U.S. has suffered 47 times more cases and 79 times more deaths than South Korea.
A recent study by researchers at University of California San Diego School of Medicine suggests transmission of COVID-19 through breast milk is not likely. The infectious virus was not detected in 64 samples of breast milk tested.
Five years ago, amid the grief and outrage surrounding the death of Freddie Gray, Johns Hopkins and the rest of Baltimore sharpened focus on making the city more just and equal. And last May, George Floyd’s death at the hands of Minneapolis police sparked a historic reckoning around race and inequality in America. Beginning Thursday, Aug. 20 at 5:00 p.m., The Johns Hopkins University and Johns Hopkins Medicine will host a free online five-part series of discussions featuring many of the nation’s most important voices on this topic.
Three Johns Hopkins Kimmel Cancer Center scientists are among the first 45 members selected to join the 10x Genomics Visium Clinical Translational Research Network (CTRN), aimed at advancing translational research in some of the world’s leading health problems, including oncology, immuno-oncology, neuroscience, infectious disease, inflammation and fibrosis, and COVID-19.
• New drug regimen for multidrug-resistant tuberculosis shows early effectiveness in 85 percent of patients in a cohort including many with serious comorbidities.
• The results suggest a global need for expanded access to two recently developed medicines, bedaquiline and delamanid.
• Study cohort included many people who would have been excluded from trials because of comorbidities, severity of disease or extent of drug resistance.
• Findings highlight the importance of innovative regimens to improve outcomes for patients with multidrug-resistant tuberculosis.
Confusion abounds about the difference between asymptomatic and pre-symptomatic infections when it comes to the pandemic coronavirus. Dr. John Lynch, medical director of infection prevention and control at Harborview, explains what it means.
As schools across the nation continue to deliberate on how and when schools will be allowed to reopen, the American Academy of Pediatrics has reported over 179,990 new COVID-19 child cases, with an overall 90% increase from July 9 –…
Recently, several physicians hosted a press conference in which one physician claimed that the combination of hydroxychloroquine, the antibiotic azithromycin and the mineral zinc could cure COVID-19. The video footage of that press conference went viral on social media, and soon many social media platforms removed the videos for providing inaccurate, non-scientifically backed claims. But questions from the public may still remain.
For a third consecutive year, the Infectious Diseases Society of America (IDSA) Foundation will showcase the IDea Incubator Pitch Competition, aimed to support entrepreneurs and researchers working in the area of infectious diseases during IDWeek 2020, October 21-25.
Human papillomavirus (HPV) is the most common sexually transmitted infection and the cause of most cervical cancers, and some vaginal, penile, anal and oral cancers. The HPV vaccine has proven effective in preventing infection and six types of HPV-attributable cancers. …
The National Institutes of Health will soon launch a phase II clinical trial to evaluate the safety and efficacy of potential new therapeutics for COVID-19, including the use of investigational synthetic monoclonal antibodies. Davey Smith of UC San Diego is the protocol chair and answers questions.
Researchers from Children’s Hospital of Philadelphia (CHOP) report important data that differentiate MIS-C from severe COVID-19 in children and suggest that MIS-C is a post-infectious syndrome related to COVID-19 but distinct from KD. The findings were published today in The Journal of Clinical Investigation.
In a pilot study of people living with HIV or high levels of cholesterol, Johns Hopkins Medicine researchers found that a six-week course of a cholesterol-lowering medication improved the function of the coronary arteries that provide oxygen to the heart.
UC San Diego Health and the Altman Clinical and Translational Research Institute will be sites for an accelerated national clinical trial to assess the efficacy and immunogenicity of a vaccine intended to protect against SARS-CoV-2, the coronavirus that causes COVID-19.
As we continue to grapple with the global pandemic, rising summer temperatures and wildfire season pose new challenges to our lung health. A team of pulmonologists and researchers at UC San Diego Health offer a wide variety of expertise and…
It seems there will never be enough “thank you’s” for the incredible doctors, nurses, technicians and support staff members who are working around the clock to help patients who have COVID-19, the dangerous coronavirus disease. The dedication, determination and spirit enable Johns Hopkins to deliver the promise of medicine.
Sharon Tapp, who worked as a nurse case manager at Veterans Affairs Medical Center in Washington, D.C., started experiencing sudden body weakness, chest pain, a high temperature and headache on March 18. Concerned, she went to her local urgent care center to find out what was wrong. They told her that these symptoms were flu-like, tested her for the coronavirus and told her to quarantine for 14 days. After five days and no difference in the presentation of her symptoms, the urgent care team contacted Sharon, letting her know that she tested positive for coronavirus and recommending that she go to the emergency department. Sharon’s family took her to Johns Hopkins Medicine’s Suburban Hospital. Because her condition worsened while at Suburban, she was transferred to The Johns Hopkins Hospital in Baltimore within 10 days of being admitted to Suburban Hospital.
Summaries of recent Fred Hutch research findings and other news.
During the novel coronavirus pandemic, many couples have concerns about reproductive consequences related to COVID-19. Experts say when it comes to the impact of infections similar to coronavirus — such as influenza — on female and male fertility, the evidence…
It seems there will never be enough “thank you’s” for the incredible doctors, nurses, technicians and support staff members who are working around the clock to help patients who have the dangerous coronavirus disease. The dedication, determination and spirit enable Johns Hopkins to deliver the promise of medicine.
There’s some good news in New Jersey about a potentially deadly tick-borne bacterium. Rutgers researchers examined more than 3,000 ticks in the Garden State and found only one carrying Rickettsia rickettsii, the bacterium that causes Rocky Mountain spotted fever. But cases of tick-borne spotted fevers have increased east of the Mississippi River, and more research is needed to understand why, according to a study in the American Journal of Tropical Medicine and Hygiene.
It seems there will never be enough “thank you’s” for the incredible doctors, nurses, technicians and support staff members who are working around the clock to help patients with the dangerous coronavirus disease. Their dedication, determination and spirit enable Johns Hopkins to deliver the promise of medicine.
In a new analysis of SARS-CoV-2, the virus that causes COVID-19, test results for nearly 38,000 people has found a positivity rate among Latinx populations about three times higher than for any other racial and ethnic group. The findings, published June 18 in the Journal of the American Medical Association (JAMA), add to evidence that there are much higher COVID-19 infection rates among U.S. minorities, particularly in Latinx communities.
If authorized for quantitative use, the assay could be used to provide a numeric result for the concentration of neutralizing anti-COVID-19 antibodies in plasma.
The number of patients visiting the emergency department (ED) for asthma treatment dropped by 76% in the first month of the COVID-19 pandemic, according to a new study by researchers at Children’s Hospital of Philadelphia (CHOP). The proportion of ED visits that led to a patient being hospitalized also decreased over this period, suggesting the decrease in overall visits was not solely due to patients avoiding the hospital due to the pandemic or delays in care for less serious asthma events.
You’re standing in the store’s check-out line, and the customer behind you viciously coughs.
Cancer researchers at Children’s Hospital of Philadelphia (CHOP) have harnessed tools used for the development of cancer immunotherapies and adapted them to identify regions of the SARS-CoV-2 virus to target with a vaccine, employing the same approach used to elicit an immune response against cancer cells to stimulate an immune response against the virus. Using this strategy, the researchers believe a resulting vaccine would provide protection across the human population and drive a long-term immune response.
Universally screening pediatric patients for COVID-19 before they undergo surgical procedures has allowed hospitals to improve safety by identifying all patients who test positive for the virus, half of whom have no symptoms, according to new research led by Children’s Hospital of Philadelphia (CHOP). The study, which analyzed universal screening procedures at CHOP and two other major children’s hospitals, found that screening patients for COVID-19 allowed hospitals to ensure patients and physicians were not exposed to the virus.
Scientists at Berkeley Lab and Stanford have joined forces to aim a gene-targeting, antiviral agent called PAC-MAN against COVID-19.
Researchers urge a moratorium on prescribing chloroquine or hydroxychloroquine, with or without azithromycin, to treat or prevent COVID-19, and caution that the reassuring safety profile of hydroxychloroquine may be more apparent than real. Safety data derive from decades of prescriptions by clinicians, primarily for their patients with lupus and rheumatoid arthritis, both of which are of greater prevalence in younger and middle age women, who are at very low risk of fatal heart outcomes due to hydroxychloroquine.
A UCLA research team has identified a new paradigm for understanding the regulation of the immune system, potentially paving the way for new approaches to treating infections and immune-related diseases such as type 1 diabetes and certain cancers.
It seems as though there will never be enough “thank-you’s” for the incredible doctors, nurses, technicians and support staff who are working around the clock to help patients with this dangerous coronavirus disease. It’s their dedication, determination and spirit that enable Johns Hopkins to deliver the promise of medicine.
Men who tested positive for COVID-19 are now being enrolled in a unique study led by the University of Miami Miller School of Medicine to determine the interaction of the virus with semen.
In a perspective piece published today in the journal Science, UC San Diego experts describe in detail the growing evidence that SARS-CoV-2, the novel coronavirus that causes COVID-19, can be spread by asymptomatic people via aerosols — a reality that…
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