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UrduWhite blood cells, which release a toxic potion of proteins to kill cancerous and virus-infected cells, are protected from any harm by the physical properties of their cell envelopes, find scientists from UCL and the Peter MacCallum Cancer Centre in…
Tag: IMMUNOLOGY/ALLERGIES/ASTHMA
Early antiretroviral treatment shrinks the HIV reservoir in infected infants
Starting antiretroviral therapy within hours of birth drastically shrinks the reservoir of HIV virus – an important step in efforts to cure infections – and improves antiviral immune responses in newborns with HIV, shows a two-year study of a unique…
MS linked to variant of common herpes virus through new method
Researchers at Karolinska Institutet have developed a new method to separate between two different types of a common herpes virus (HHV-6) that has been linked to multiple sclerosis. By analyzing antibodies in the blood against the most divergent proteins of…
Immunity — master regulator of liver metabolism identified during infection
Surprisingly, the antiviral cytokine type I interferon (IFN-I) was found to be a master regulator of metabolic pathways in liver cells. The researchers focused on the urea cycle, a central metabolic node, and found that it is disrupted by IFN-I…
MS linked to variant of common herpes virus through new method
Researchers at Karolinska Institutet have developed a new method to separate between two different types of a common herpes virus (HHV-6) that has been linked to multiple sclerosis. By analyzing antibodies in the blood against the most divergent proteins of…
Immunity — master regulator of liver metabolism identified during infection
Surprisingly, the antiviral cytokine type I interferon (IFN-I) was found to be a master regulator of metabolic pathways in liver cells. The researchers focused on the urea cycle, a central metabolic node, and found that it is disrupted by IFN-I…
Crossing borders and growing resistance: a superbug from south Asia
Using whole genome sequencing, researchers have been able to trace the origins and global spread of a multi-drug resistant, community Staphylococcus aureus lineage from the Indian subcontinent, known as the Bengal Bay clone
A protein tag to study the immune system
Researchers from VIB-UGent Center for Medical Biotechnology, University of Iowa (USA) and other collaborators, developed a novel approach to better understand a basic defense mechanism of our immune system. Central is ISG15, a small protein with a role in the…
Linking wound healing and cancer risk
When our skin is damaged, a whole set of biological processes springs into action to heal the wound. Now, researchers from the VIB-UGent Center for Inflammation Research have shown that one of the molecules involved in this, HMGB1, slows down…
Crossing borders and growing resistance: a superbug from south Asia
Using whole genome sequencing, researchers have been able to trace the origins and global spread of a multi-drug resistant, community Staphylococcus aureus lineage from the Indian subcontinent, known as the Bengal Bay clone
A protein tag to study the immune system
Researchers from VIB-UGent Center for Medical Biotechnology, University of Iowa (USA) and other collaborators, developed a novel approach to better understand a basic defense mechanism of our immune system. Central is ISG15, a small protein with a role in the…
Linking wound healing and cancer risk
When our skin is damaged, a whole set of biological processes springs into action to heal the wound. Now, researchers from the VIB-UGent Center for Inflammation Research have shown that one of the molecules involved in this, HMGB1, slows down…
Uncontrolled asthma attacks during pregnancy increase health risks for mothers and babies
Women with asthma who suffer severe symptoms while they are pregnant face higher risks of health problems both for themselves and their babies compared to women with well-controlled asthma, according to research published in the European Respiratory Journal [1]. The…
Newly discovered immune cells contribute to toxic shock
Recently discovered immune cells called MAIT cells play a key role in group A streptococcal toxic shock, researchers at Karolinska Institutet in Sweden report. The results, which are published in the journal PNAS , have potential implications for the diagnosis…
The ‘Signal Cell’ relaying microbiota signals discovered
Microorganisms are considered as dirty organism that threaten our health, decay food and cause inconvenience in our daily life. However, they are playing a critical role in making nutrients by metabolizing food, allowing all living creatures to live on. Especially,…
Search for the source of antibodies would help treat allergies
Researchers of Sechenov University together with their colleagues from Russia and Austria summarised everything known about cells producing group E antibodies. These molecules are responsible for most of the allergic reactions, including such dangerous diseases as asthma, Quincke’s edema and…
Newly discovered immune cells contribute to toxic shock
Recently discovered immune cells called MAIT cells play a key role in group A streptococcal toxic shock, researchers at Karolinska Institutet in Sweden report. The results, which are published in the journal PNAS , have potential implications for the diagnosis…
The ‘Signal Cell’ relaying microbiota signals discovered
Microorganisms are considered as dirty organism that threaten our health, decay food and cause inconvenience in our daily life. However, they are playing a critical role in making nutrients by metabolizing food, allowing all living creatures to live on. Especially,…
Search for the source of antibodies would help treat allergies
Researchers of Sechenov University together with their colleagues from Russia and Austria summarised everything known about cells producing group E antibodies. These molecules are responsible for most of the allergic reactions, including such dangerous diseases as asthma, Quincke’s edema and…
New Cochrane Review assesses different HPV vaccines & vaccine schedules in adolescent girls and boys
New evidence published in the Cochrane Library today provides further information on the benefits and harms of different human papillomavirus (HPV) vaccines and vaccine schedules in young women and men. HPV is the most common viral infection of the reproductive…
$1M grant goes to asthma prevention research
UMass Lowell prof leads effort to aid low-income seniors
Dissecting connections between chronic stress, inflammation and depression
AUGUSTA, Ga. (Nov. 21, 2019) – Chronic stress can inflame our brain, destroy the connections between our neurons and result in depression, scientists say. Now they are working to better understand how the destructive cycle happens and how best to…
Unruly T cells complicate the intended benefits of HIV vaccines
Inducing strong responses from T helper (TH) cells – long seen as a desirable goal for HIV vaccines – and using multiple antigens can hamper the effectiveness of vaccine candidates for HIV, according to an analysis of macaque experiments and…
Atopic eczema linked to increase fracture risk in adults
Targeted testing and fracture-prevention strategies should be considered for these individuals
Could sphingolipids help solve a racial paradox in heart disease?
When it comes to predicting heart disease in African Americans, measuring HDL and LDL cholesterol is not enough. A Medical University of South Carolina study suggests that sphingolipid levels could one day hold the key
Non-invasive microscopy detects activation state and distinguishes between cell types
Most analytical methods in biology require invasive procedures to analyze samples, which leads to irreversible changes or even their destruction. Furthermore, the sensitivity of such approaches often stems from the averaging of signals generated by a large number of cells,…
Experimental HIV vaccine successfully elicits broadly neutralizing antibodies to the virus
Vaccinated rabbits produce antibodies to at least two vulnerable sites on HIV
A new pathway to ‘reprogram’ killer cells
The so-called natural killer (NK) cells are cells of the innate immune system that recognize and eliminate infected cells or cancer cells. During a virus infection, NK cells also keep the body’s own immune cells such as the T cells…
Malaria discovery could lead to better HIV and lupus treatments
A discovery about how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus, say Australian researchers. The research team showed, in laboratory models, that strong inflammatory signals caused by malaria infection…
Evidence in mice that childhood asthma is influenced by the neurotransmitter dopamine
Neurons that produce the neurotransmitter dopamine communicate with T cells to enhance allergic inflammation in the lungs of young mice but not older mice, researchers report November 19 in the journal Immunity . The findings potentially explain why asthma susceptibility…
A new pathway to ‘reprogram’ killer cells
The so-called natural killer (NK) cells are cells of the innate immune system that recognize and eliminate infected cells or cancer cells. During a virus infection, NK cells also keep the body’s own immune cells such as the T cells…
Malaria discovery could lead to better HIV and lupus treatments
A discovery about how the immune system responds to malaria infection could lead to better treatments for hepatitis C, HIV and lupus, say Australian researchers. The research team showed, in laboratory models, that strong inflammatory signals caused by malaria infection…
Evidence in mice that childhood asthma is influenced by the neurotransmitter dopamine
Neurons that produce the neurotransmitter dopamine communicate with T cells to enhance allergic inflammation in the lungs of young mice but not older mice, researchers report November 19 in the journal Immunity . The findings potentially explain why asthma susceptibility…
Tailored T-cell therapies neutralize viruses that threaten kids with PID
Tailored T-cells specially designed to combat a half dozen viruses are safe and may be effective in preventing and treating multiple viral infections, according to research led by Children’s National Hospital faculty. Catherine Bollard, M.B.Ch.B., M.D., director of the Center…
Tailored T-cell therapies neutralize viruses that threaten kids with PID
Tailored T-cells specially designed to combat a half dozen viruses are safe and may be effective in preventing and treating multiple viral infections, according to research led by Children’s National Hospital faculty. Catherine Bollard, M.B.Ch.B., M.D., director of the Center…
From childhood cancer to mapping human development
Pioneering scientist awarded 2019 Foulkes Foundation medal
Article proposes important mucin link between microbial infections and many cancers
It is generally known that viruses, with their cell-invading capabilities, can be responsible for a number of different cancers. What is less broadly discussed are the cancer-causing capabilities of bacteria, or the processes by which they may cause malignancy. In…
Scientists discover how the molecule-sorting station in our cells is formed and maintained
New mechanism to explain how the cell organelle that sorts and distributes substances entering a cell is formed and maintained
CSU lands $1.2 million in NIH funding to advance work on a new tuberculosis vaccine
A team of researchers in the Department of Microbiology, Immunology and Pathology at Colorado State University aim to advance what is known about the complex immune response necessary to prevent tuberculosis disease. The university was recently awarded a $1.2 million…
Integral Molecular to advance vaccine discovery with NIH contract for $5.5 million
PHILADELPHIA – The National Institute of Allergy and Infectious Diseases (NIAID) has awarded Integral Molecular a contract (75N93019C00073) which will provide up to $5.5M over the next five years to define antibody responses to pathogenic viruses including Zika, Marburg and…
Integral Molecular to advance vaccine discovery with NIH contract for $5.5 million
PHILADELPHIA – The National Institute of Allergy and Infectious Diseases (NIAID) has awarded Integral Molecular a contract (75N93019C00073) which will provide up to $5.5M over the next five years to define antibody responses to pathogenic viruses including Zika, Marburg and…
Scientists spearhead ‘major step forward’ for malaria vaccine
Researchers have narrowed down the malaria proteins and disease-fighting antibodies that could be used to develop a vaccine against the most severe forms of malaria. Associate Professor Alyssa Barry, who was recently appointed to lead the Systems Epidemiology of Infection…
Twenty-seven life scientists become EMBO Young Investigators
Heidelberg, 13 November 2019 – EMBO congratulates twenty-seven life scientists on their selection as new EMBO Young Investigators. They join a network of 129 current and 340 former Young Investigators, and will begin their four-year programme tenure in January 2020.…
Could cytotoxic T-cells be a key to longevity?
Scientists from the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine in Japan have used single-cell RNA analysis to find that supercentenarians–meaning people over the age of 110–have an excess of a type of immune…
Scientists spearhead ‘major step forward’ for malaria vaccine
Researchers have narrowed down the malaria proteins and disease-fighting antibodies that could be used to develop a vaccine against the most severe forms of malaria. Associate Professor Alyssa Barry, who was recently appointed to lead the Systems Epidemiology of Infection…
Twenty-seven life scientists become EMBO Young Investigators
Heidelberg, 13 November 2019 – EMBO congratulates twenty-seven life scientists on their selection as new EMBO Young Investigators. They join a network of 129 current and 340 former Young Investigators, and will begin their four-year programme tenure in January 2020.…
Could cytotoxic T-cells be a key to longevity?
Scientists from the RIKEN Center for Integrative Medical Science (IMS) and Keio University School of Medicine in Japan have used single-cell RNA analysis to find that supercentenarians–meaning people over the age of 110–have an excess of a type of immune…
$1.85 million NIH grant to study sepsis
One drop of blood contains 5,000 neutrophils, the most abundant type of white blood cell that is deployed by the human immune system. Throughout the entire body, a human has 25 billion of these foot soldiers that are relentlessly patrolling…
Boosting host immune defenses to treat tuberculosis
Current treatment regimens for Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, are long, complex, and hard for people to sustain. Moreover, the bacteria often develop drug resistance, and many people harbor multi-drug-resistant strains. In 2018 alone, nearly 1.5 million…
Scientists identify immune cells linked to malaria-induced anaemia through autoantibody production
Anaemia in malaria patients is likely caused by an autoimmune attack on uninfected red blood cells, suggesting a new approach to treating this deadly side effect