A study of a herpes virus that infects chickens offers new insights into potentially problematic interactions between vaccines made from live viruses and the viruses they are meant to thwart.
A study led by UC Davis Cancer Center identified a binding protein in cancer cell’s nucleus, known as CHD4, as a critical agent keeping Kaposi’s sarcoma-associated herpesvirus (KSHV) dormant and undetected by the body’s immune system. CHD4 is linked to cancer cell growth in many types of cancers.
The finding could lead to new ways to prevent cold sores and herpes-related eye disease from reoccurring, the researchers report.
Scientists used a 3D human tissue culture model mimicking the components and conditions in the brain to demonstrate a possible causal relationship between Alzheimer’s disease and herpes simplex virus I infection (HSV-1). The model will allow further studies into the causes and possible treatments of this devastating neurodegenerative condition.