A new study led by scientists at Sanford Burnham Prebys has shown that the protein RNF5 plays an unusual role in acute myeloid leukemia (AML). Unlike its expected role, marking aberrant proteins for destruction, RNF5 binds with a second cell protein called RBBP4 to control expression of genes implicated in AML. These findings, published in Nature Communications, have important implications for improving AML patient outcomes.
Tag: Hdac Inhibitors
Study reports chemical mechanism that boosts enzyme observed in cancer
A study led by researchers at IUPUI and Indiana University Bloomington is the first to describe a biochemical mechanism that influences activity in a protein linked to cancer, aging, inflammatory responses and addiction-related behaviors.
Study: Enzyme Could Prove Effective in Treating Tumors and Inflammatory Diseases in Lung
Findings from a research study, led by scientists at Henry Ford, suggest an enzyme could play an important role in the treatment of cancer and autoimmune diseases in the airway.