The Oncotarget author’s data suggest in vitro proof-of-concept that supports inhibition of mitochondrial ATP synthase and ROS generation as contributors to the effectiveness of CADD522 in suppression of tumor growth
Tag: CARCINOGENS
Cancer’s dangerous renovations to our chromosomes revealed
Cancer remodels the architecture of our chromosomes so the disease can take hold and spread, researchers at the University of Virginia have revealed. This remodeling is important because the arrangement of the components in our chromosomes actually affects the workings…
Oncotarget: KDM5A and PHF2 positively control expression of pro-metastatic genes
The cover for Issue 43 of Oncotarget features Figure 6, ‘(A) Following the experimental protocol of Franzetti et al. [11] A673-shA1c cells ?/+ Dox (EWS/Fli1high/EWS/Fli1low) were injected into the tail vein, and metastases were allowed to form in…
Oncotarget: An integrative microenvironment approach for follicular lymphoma
Oncotarget Volume 11, Issue 33 features Figure 8, ‘Haplotype estimates in follicular lymphoma patients,’ by Assis-Mendonça, et al.
Dartmouth study examines well water testing promotion in pediatric primary care
Findings from a new study conducted by a team of researchers at Dartmouth’s Geisel School of Medicine and published in the journal Preventive Medicine Reports , show that involving pediatric practices in the promotion of private well water testing can…
Oncotarget: Survival after resection of brain metastases: A matched cohort analysis
The cover for issue 32 of Oncotarget features Figure 2, ‘This figure depicts overall survival and local in-brain recurrence-free survival in the study’s subgroups,’ by Hussein, et al.
Oncotarget: Evaluation of cellular alteration & inflammatory profile of cells
Oncotarget recently published “Evaluation of cellular alterations and inflammatory profile of mesothelial cells and/or neoplastic cells exposed to talc used for pleurodesis”
Oncotarget: A novel format for recombinant antibody-interleukin-2 fusion proteins
Oncotarget recently published a novel format for recombinant antibody-interleukin-2 fusion proteins exhibits superior tumor-targeting properties in vivo which reported that here, the authors describe four novel formats for the L19-IL2 fusion
$14 million grant to support Pacific Islander cancer research
Funds will continue a 17-year partnership between University of Guam and University of Hawai’i Cancer Center
Thymoquinone induces apoptosis & DNA damage in 5-Fluorouracil-resistant colorectal cancer
Volume 11, Issue 31 from @Oncotarget reported that TQ decreased the expression levels of colorectal stem cell markers CD44 and Epithelial Cell Adhesion Molecule Ep CAM and proliferation marker Ki67 in colonospheres derived from both cell lines and…
Oncotarget: Sirolimus-eluting stents — opposite in vitro effects on the clonogenic cell potential
The cover for issue 31 of Oncotarget features Figure 4, ‘Concentration dose-response curves of sirolimus effect [55 nM-1 nM] on the number of cells per surviving colony in U2OS cell line after 2 weeks exposure,’ by Vasuri, et al.
Cutting cancer off at the head
Osaka City University detects cancer cells in 2ml blood samples and connects them back to their origin tumor — creating a new diagnostic tool that may aid in quicker and more accurate anti-cancer measures
Salk’s Dannielle Engle awarded over $1 million to study tobacco use on pancreatic cancer
LA JOLLA–(October 21, 2020) Salk Institute Assistant Professor Dannielle Engle has been awarded a New Investigator Award from the Tobacco-Related Disease Research Program (TRDRP) to examine how tobacco use promotes cellular changes that lead to pancreatic cancer. The TRDRP funds…
Oncotarget: quantitative ultrasound radiomics in prediction of treatment response for breast cancer
The cover for Issue 42 of Oncotarget features Figure 4, “Generation of parametric and texture maps from radiofrequency data,” recently published in “Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adj
UC studies tobacco use, cancer connection
Research shows that tobacco use changes the metabolism of a type of kidney cancer which could lead to individualized treatment
Oncotarget: cGAS-STING pathway in oncogenesis and cancer therapeutics
Oncotarget Volume 11, Issue 30 reported that recent evidence shows that the host innate immunity is also critical in sensing the presence of cytoplasmic DNA derived from genomic instability events, such as DNA damage and defective cell cycle progression
Oncotarget: Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast
Oncotarget Volume 11, Issue 30 reported that genomic profiling of murine mammary tumor cells with differential VDR expression identified 35 transcripts that were altered by the 1,25D3-VDR complex including Hyaluronan Synthase-2
UArizona Health Sciences researchers find biomarker that can appear before stomach cancer
A promising new biomarker that appears in patients before stomach cancer develops may help with early detection of the disease and improve patient response to therapy, according to findings in a study led by University of Arizona Health Sciences researchers.…
LSU Health New Orleans review suggests HNB tobacco products may threaten health
New Orleans, LA – A review of heat-not-burn (HNB) tobacco products from the laboratory of Dr. Jason Gardner, Professor of Physiology at LSU Health New Orleans School of Medicine, reports an association with elevated blood pressure, increased heart rate, cell…
Oncotarget: Th1 cytokines potentiate apoptosis of breast cancer cells and suppress tumor growth
Volume 11, Issue 30 of Oncotarget reported that previously, the authors showed that anti-estrogen drugs combined with a dendritic cell-based anti-HER-2 vaccine known to induce strong Th1-polarized immunity dramatically improved clinical response rates in
Oncotarget: Induction of phenotypic changes in HER2-postive breast cancer cells
The cover for issue 30 of Oncotarget features Figure 4, “RNAseq results demonstrating differences between normal, cancer, and redirected cells,” by Frank-Kamenetskii, et al. which reported that the influence of breast cancer cells on normal cells of the m
Oncotarget: Geriatric nutritional risk index – prognostic marker of esophageal carcinoma
Oncotarget Volume 11, Issue 29 reported that In multivariate analyses, serum albumin, GNRI, pathological tumor-node-metastasis stage, and tumor differentiation were independent prognostic factors for CSS.
Oncotarget: Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance
Oncotarget Volume 11, Issue 29 reported that Immunosuppressive chemoresistance is a major burden in lung cancer.
Golden meat: Engineering cow cells to produce beta carotene
Scientists prove cell-cultured meat products can offer enhanced nutrition compared to conventionally produced meat
Oncotarget: Genomic markers of midostaurin drug sensitivity in leukemia patients
Oncotarget Volume 11, Issue 29 reported that acute myeloid leukemia is a heterogeneous malignancy with the most common genomic alterations in NPM1, DNMT3A, and FLT3. Midostaurin was the first FLT3 inhibitor FDA approved for AML and is standard of care for
Oncotarget: Efavirenz induces DNA damage response pathway in lung cancer
The cover for Issue 41 of Oncotarget features Figure 7, “IPA ATM-signaling pathway in (A) EFV treated MRC-5 and (B) A549 cells,” recently published in “Efavirenz induces DNA damage response pathway in lung cancer” by Marima, et al. which reported that the
Oncotarget: miR-708-5p targets oncogenic prostaglandin E2 production in lung cancer cell
Volume 11, Issue 26 of Oncotarget reported that Lung cancer is of particular importance, as it is the deadliest cancer worldwide.
Oncotarget: The role of miRNA-133b and its target gene SIRT1 in FAP-derived desmoid tumor
Volume 11, Issue 26 of Oncotarget reported that in this study the authors studied the differences in mi RNA expression between sporadic and FAP-associated Desmoid tumors using microarray confirmed by quantitative PCR.
Oncotarget: Cooperative tumorigenic effects of targeted deletions of tumor suppressors
Volume 11, Issue 28 of Oncotarget features “Genetic analysis of the cooperative tumorigenic effects of targeted deletions of tumor suppressors Rb1, Trp53, Men1, and Pten in neuroendocrine tumors in mice” by Xu et, al. which reported that the authors exami
Oncotarget: Characterization of porcine hepatocellular carcinoma for liver cancer
Volume 11, Issue 28 of Oncotarget features “Development and comprehensive characterization of porcine hepatocellular carcinoma for translational liver cancer investigation” by Gaba et, al. which reported that reliable development of Oncopig HCC cell lines
Oncotarget: Rapid onset type 1 diabetes with anti-PD-1 directed therapy
Volume 11, Issue 28 of Oncotarget features ‘Rapid onset type 1 diabetes with anti-PD-1 directed therapy’, by Yun et al. and reported that Type 1 diabetes is a rare immune-related adverse event caused by checkpoint inhibitors with serious risk for diabetic
Oncotarget: Exosomes secreted under hypoxia enhance stemness in Ewing’s sarcoma
The cover for issue 40 of Oncotarget features Figure 5, ‘miR-210 silences the proapoptosis member CASP8AP2,’ by Kling, et al. which reported that hypoxic Ewing’s sarcoma cells release exosomes that promote sphere formation, a stem-like phenotype, in EWS
Novel digital dashboard improves cancer case review efficiency
Dashboard reduced preparation time by 30%, improved access to data and decision-making
New tools improve care for cancers that spread to the brain
Ambitious efforts at UVA Cancer Center to improve care delivered to patients with cancer that has spread to the brain have yielded important insights and tools that can benefit other hospitals, a new publication reports. The tools include the first…
Pathogens in the mouth induce oral cancer
Pathogens found in tissues that surround the teeth contribute to a highly aggressive type of oral cancer, according to a study published 1st October in the open-access journal PLOS Pathogens by Yvonne Kapila of the University of California, San Francisco,…
Consumers who avoid products with harmful chemicals on the label have lower body burden
Reading ingredient labels reduces exposures to many endocrine disruptors — but not all
New technologies link treatments to the patients who need them the most
Researchers at the Medical University of South Carolina and Hollings Cancer Center explore remote methods for conducting smoking cessation clinical trials
Oncotarget: A comprehensive analysis of clinical trials in pancreatic cancer
The cover for issue 38 of Oncotarget features Figure 3, ‘Summary of the time and cost for drug development (modified from DiMasi et al [2016],’ by Katayama, et al. which reported that Pancreatic cancer is the most aggressive common cancer and is desperate
No benefit for post-operative radiotherapy in non-small-cell lung cancer
Data from latest research presented at the ESMO Virtual Congress 2020
There’s no place like home: Cleaning toxic tobacco smoke residue in our homes
San Diego, CA – The COVID-19 pandemic has created a number of challenges, including that many are spending more time at home than ever before. This is a significant problem for those with neighbors who smoke. Smoking continues to be…
University of South Carolina study reveals how cannabinoids may be useful to prevent colon cancer
COLUMBIA, SC — Inflammatory bowel diseases (IBD) such as Crohn’s disease and ulcerative colitis are caused by unrestrained inflammation of the gastrointestinal tract. Patients with IBD are at a higher risk of developing colorectal cancer. In a recent study published…
uOttawa Ph.D. student receives Fire Researcher of the Year Award
Jennifer Keir, a uOttawa PhD student and Research Associate whose research investigates firefighters’ health and their occupational exposure to hazardous substances, has been named the 2020 Fire Researcher of the Year by the Canadian Fire Chiefs Association. In October 2017,…
Oncotarget: GATA3 and APOBEC3B are prognostic markers in adrenocortical carcinoma
The cover for issue 36 of Oncotarget features Figure 7, ‘Knockdown of APOBEC3B is associated with a lower tumor growth in an adrenocortical carcinoma xenograft mouse model,’ by Gara, et al. which reported that the role of APOBEC3B in adrenocortical carcin
IU researcher awarded $5.7 million to study chemo-induced hearing loss, toxicities
INDIANAPOLIS–A researcher at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center has been awarded a five-year, $5.7 million National Cancer Institute grant to evaluate long-term health outcomes for cancer patients who receive platinum-based chemotherapies. An internationally recognized expert…
High levels of toxic flame retardant chemicals found in dust inside college classrooms
School spaces with newer furniture show significantly lower levels of hazardous exposures
‘Social smokers’ face disproportionate risk of death from lung disease and lung cancer
‘Social smokers’ are more than twice as likely to die of lung disease and more than eight times as likely to die of lung cancer than non-smokers, according to research presented at the European Respiratory Society International Congress. [1] The…
Studies: E-cigarettes Don’t Help Smokers Quit and They May Become Addicted to Vaping
Two UC San Diego School of Medicine-led analyses report that e-cigarettes are not effective in helping adults to quit smoking.
Studies: E-cigarettes won’t help smokers quit, but they may become addicted to vaping
E-cigarettes are now the most popular product used for smoking cessation in the United States, ahead of all U.S. Food and Drug Administration (FDA)-approved cessation aids combined, from nicotine patches and gum to prescription medications. However, two recently published analyses…
Firefighters exposed to more potentially harmful chemicals than previously thought
CORVALLIS, Ore. – A new Oregon State University study suggests that firefighters are more likely to be exposed to potentially harmful chemicals while on duty compared to off duty. The on-duty firefighters in the Kansas City, Missouri, area experienced higher…
How viral infections associated with cancer become persistent?
Study discovers novel functions of viral protein