Scientists at Dartmouth’s Norris Cotton Cancer Center make a direct connection between dietary fat and cancer cell biology by showing that fat particles from the blood are taken into breast cancer cells through a novel mechanism
Tag: Cancer
Metabolic adaptation ensures survival of colon cancer cells
Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to adapt to the lack of oxygen and nutrients inside the tumor. Statins, which are often prescribed to lower…
New potential cancer players revealed by extensive tumor protein analysis
Looking to gain a deeper understanding of cancer, a team led by researchers at Baylor College of Medicine conducted an extensive computational analysis of the similarities and differences in the entire set of proteins, called the proteome, of more than…
The danger behind certain biologics
The surprising role of an immune cell that explains some of the drugs’ side effects and could lead to better treatments for persistent infections and cancer.
IBIS-II study finds anastrozole reduces breast cancer rates for high risk postmenopausal women
The Queen Mary University of London professor leading an international breast cancer study says anastrozole – rather than tamoxifen – should be the preventive drug-of-choice for post-menopausal women at increased risk of developing the disease. Anastrozole, which inhibits the production…
10-year results of NRG Oncology/NSABP B-42 trial
Extended letrozole therapy improves disease-free survival (DFS) in postmenopausal women with HR+ breast cancer
Black/white breast cancer subtype incidence in men differs from trends in women
Profile variations may point to causal factors
Ultrasound blasts potent glioblastoma drug into brain tumor
Treatment successfully delivers drug across the blood-brain barrier directly to brain tumor in mice
Breast cancer cells swallow a ‘free lunch’ of dietary fat particles from the bloodstream
Scientists at Dartmouth’s Norris Cotton Cancer Center make a direct connection between dietary fat and cancer cell biology by showing that fat particles from the blood are taken into breast cancer cells through a novel mechanism
Chemists’ calculations may advance cancer prediction
Rice University scientists’ approach to cell dynamics builds new view of lifetime risk
Metabolic adaptation ensures survival of colon cancer cells
Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to adapt to the lack of oxygen and nutrients inside the tumor. Statins, which are often prescribed to lower…
Deadly ‘superbugs’ destroyed by molecular drills
Rice, Texas A&M-led research shows motors kill bacteria, revive some antibacterial drugs
The danger behind certain biologics
The surprising role of an immune cell that explains some of the drugs’ side effects and could lead to better treatments for persistent infections and cancer.
Statement advising caution on interpretation of recent paper on cancer risk & hyperthyroidism issued
by the Society for Endocrinology and British Thyroid Association
10-year results of NRG Oncology/NSABP B-42 trial
Extended letrozole therapy improves disease-free survival (DFS) in postmenopausal women with HR+ breast cancer
Breast cancer patients to be evaluated for genetic testing
According to a statement on behalf of the American College of Medical Genetics and Genomics (ACMG) published Dec. 13 in the organization’s official journal, Genetics in Medicine , there is insufficient evidence to recommend universal genetic testing for BRCA1/2 alone…
Ultrasound blasts potent glioblastoma drug into brain tumor
Treatment successfully delivers drug across the blood-brain barrier directly to brain tumor in mice
New potential cancer players revealed by extensive tumor protein analysis
Looking to gain a deeper understanding of cancer, a team led by researchers at Baylor College of Medicine conducted an extensive computational analysis of the similarities and differences in the entire set of proteins, called the proteome, of more than…
Chemists’ calculations may advance cancer prediction
Rice University scientists’ approach to cell dynamics builds new view of lifetime risk
Deadly ‘superbugs’ destroyed by molecular drills
Rice, Texas A&M-led research shows motors kill bacteria, revive some antibacterial drugs
Statement advising caution on interpretation of recent paper on cancer risk & hyperthyroidism issued
by the Society for Endocrinology and British Thyroid Association
IBIS-II study finds anastrozole reduces breast cancer rates for high risk postmenopausal women
The Queen Mary University of London professor leading an international breast cancer study says anastrozole – rather than tamoxifen – should be the preventive drug-of-choice for post-menopausal women at increased risk of developing the disease. Anastrozole, which inhibits the production…
Black/white breast cancer subtype incidence in men differs from trends in women
Profile variations may point to causal factors
Jersey Shore University Medical Center Receives Re-Accreditation from the National Accreditation Program for Breast Centers
Hackensack Meridian Health Jersey Shore University Medical Center achieved re-accreditation from the National Accreditation Program for Breast Centers (NAPBC), a program administered by the American College of Surgeons.
Immune outposts inside kidney tumors predict post-surgery outcomes
T cell infiltration => longer progression-free survival
Tucatinib ‘game changing’ against HER2+ breast cancer, especially with brain metastases
Phase III clinical trial results reported today in the New England Journal of Medicine and presented concurrently at the San Antonio Breast Cancer Symposium (SABCS) 2019 show the combination of the investigational drug tucatinib with standard of care treatment including…
A way to ‘fingerprint’ human cells
Researchers say a new method to analyse data from individual human cells could be a step-change for diagnosing some of the most devastating diseases, including cancer and autoimmune disease. By combining single cell analysis techniques with machine learning algorithms, a…
Flipping the script on novel cancer therapy leads to insights into lupus
In the last decade, scientists discovered that blocking a key regulator of the immune system helped unleash the body’s natural defenses against several forms of cancer, opening up a new era of cancer immunotherapy. Now Yale scientists have essentially flipped…
New insights to major disease pathways
Chemical tool identifies hundreds of modified proteins
Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation
The cover for issue 65 of Oncotarget features Figure 7, ‘EGFR activated cases compared to pathway markers,’ by Kucherlapati, et al.
Mechanisms help pancreatic cancer cells avert starvation
A new study reveals the mechanism that helps pancreatic cancer cells avoid starvation within dense tumors by hijacking a process that pulls nutrients in from their surroundings. Led by researchers at NYU Grossman School of Medicine, the study explains how…
Site search: A digital approach to proteins and cancer
WEST LAFAYETTE, Ind. – What if scientists could create more effective drugs to treat cancers and other diseases by better targeting specific sites on proteins in the body? That’s the primary question researchers in the Purdue University laboratory of Carol…
Tropical flower offers potential new route for treating pancreatic cancer
An international team of scientists led by the University of Bath have made drug-like molecules inspired by a chemical found in a tropical flower, that they hope could in the future help to treat deadly pancreatic cancer. Pancreatic cancer is…
Tucatinib ‘game changing’ against HER2+ breast cancer, especially with brain metastases
Phase III clinical trial results reported today in the New England Journal of Medicine and presented concurrently at the San Antonio Breast Cancer Symposium (SABCS) 2019 show the combination of the investigational drug tucatinib with standard of care treatment including…
New insights to major disease pathways
Chemical tool identifies hundreds of modified proteins
Modulation of proliferation factors in lung adenocarcinoma with an analysis of the transcriptional consequences of genomic EGFR activation
The cover for issue 65 of Oncotarget features Figure 7, ‘EGFR activated cases compared to pathway markers,’ by Kucherlapati, et al.
Flipping the script on novel cancer therapy leads to insights into lupus
In the last decade, scientists discovered that blocking a key regulator of the immune system helped unleash the body’s natural defenses against several forms of cancer, opening up a new era of cancer immunotherapy. Now Yale scientists have essentially flipped…
Promising new approach to treating some of the worst types of leukaemia
MLL-r leukaemia claims the lives of many of those affected, while those who survive are often left with serious long-term effects
Mechanisms help pancreatic cancer cells avert starvation
A new study reveals the mechanism that helps pancreatic cancer cells avoid starvation within dense tumors by hijacking a process that pulls nutrients in from their surroundings. Led by researchers at NYU Grossman School of Medicine, the study explains how…
Hyperactive FOXA1 reprograms endocrine-resistant breast cancer to become metastatic
A team led by researchers at Baylor College of Medicine and Harvard Medical School has unveiled a novel mechanism that helps explain how endocrine-resistant breast cancer acquires metastatic behavior, opening the possibility of new therapeutic strategies. Published in the Proceedings…
Site search: A digital approach to proteins and cancer
WEST LAFAYETTE, Ind. – What if scientists could create more effective drugs to treat cancers and other diseases by better targeting specific sites on proteins in the body? That’s the primary question researchers in the Purdue University laboratory of Carol…
Novel respiratory cell changes identified from cigarette smoke exposure
Changes may result in therapies to prevent the development of lung cancer
Tropical flower offers potential new route for treating pancreatic cancer
An international team of scientists led by the University of Bath have made drug-like molecules inspired by a chemical found in a tropical flower, that they hope could in the future help to treat deadly pancreatic cancer. Pancreatic cancer is…
Yale Cancer Center researchers investigate inducing “synthetic lethality” in two blood and bone cancers
In a clinical trial led by Yale Cancer Center (YCC) and Smilow Cancer Hospital, researchers aim to exploit DNA mutations in the treatment of two blood and bone marrow cancers, a different tacit than the more traditional approach of blunting or switching off genetic mutations linked to cancer
Immunotherapy drug improves outcomes for some children with relapsed leukemia
New findings from a clinical trial show that treatment with the immunotherapy drug blinatumomab is superior to standard chemotherapy for children and young adults with high- or intermediate-risk B-cell acute lymphoblastic leukemia (B-ALL) that has relapsed. Those treated with blinatumomab…
AGA releases guideline on management of gastric intestinal metaplasia
Bethesda, MD (Dec. 6, 2019) — Gastric intestinal metaplasia (GIM), which is linked to non-cardia gastric cancer, is often detected during routine endoscopy, leading to questions about how patient care should be managed. A new clinical guideline1 from the American…
ASTRO issues new guideline on radiation therapy for basal, squamous cell skin cancers
Recommendations define how and when radiation therapy should be used to treat the most common types of skin cancer
Drug combination shows promise in preclinical models of triple negative breast cancer
Hollings Cancer Center researchers explore how to help the 60 percent of patients with TNBC who do not respond well to more traditional treatments
Research sheds important light on the metastasis of neuroblastoma
The findings, published in British Journal of Cancer, were discovered by Professor Maria Kavallaris and her team could potentially lead to new treatment
New Mayo Clinic studies to be presented at American Society of Hematology meeting
Mayo Clinic researchers will present findings at the American Society of Hematology Annual Meeting Dec. 7–10 in Orlando.
New Mayo Clinic studies to be presented include:
DNA analysis identifies elevated risk factor for myeloma in individuals of African ancestry
Study identifies more precise assessment measures for patients newly diagnosed with chronic lymphocytic leukemia
Researchers develop method to assess cancer-fighting cell therapy’s effectiveness