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UrduBiomedical scientists are increasingly using deconvolution methods, those used to computationally analyze the composition of complex mixtures of cells. One of their challenges is to select one method that is appropriate for their experimental conditions among nearly 50 available. To…
Tag: Bioinformatics
Researchers reveal aging signatures across diverse tissue cells in mice
Comprehensive analyses provide new biological insights on the aging process in mice and will aid future studies on aging and related topics
Cancer DNA blood tests validated by international research team
An international team today reports the findings of an independent assessment of five commercially-available assays for tumour DNA sequencing – a fast, cheap and less invasive method to diagnose and monitor cancer. The researchers revealed that all assays could reliably…
The best in AI appointed at Norwich Research Park
Scientists across Norwich Research Park institutes are part of a major integrated UK research-industry programme led by The Alan Turing Institute, seeking out the best talent in AI and data science, developing bioscience leaders and supporting the UK economy. The…
The future of biodiversity collections
Events such as the COVID-19 pandemic have highlighted the crucial role played by biodiversity collections in enabling rapid responses to crises and in facilitating ongoing research across numerous fields. Despite the recognized value of this infrastructure, the community nevertheless has…
Singapore launches next phase of National Precision Medicine Programme
SINGAPORE, 7 April 2021 – Precision medicine is part of Singapore’s Research, Innovation and Enterprise (RIE) 2025 strategic goal to transform and protect the health of every Singaporean. Identified as a priority by the Ministry of Health, precision medicine aims…
Gained in translation: Subgenome fractionation determines hybrid vigor in maize
Researchers trace the root of increased hybrid vigor in maize to differential translational fractionation of its subgenomes
Novel biomarker for glucocorticoids could help tailor treatments
A clinical study finds a biomarker for the action of glucocorticoids that could be used for developing tests to help clinicians tailor treatments
Scientists launch ‘herculean’ project creating atlas of human genome variants
SEATTLE (April 1, 2021) – An international consortium of geneticists, biologists, clinicians, mathematicians, and other scientists is determined to take the study of the human genome to the next level – creating a comprehensive atlas of genetic variants to advance…
Building a culture of high-quality data
The era of big data has inundated nearly all scientific fields with torrents of newly available data with the power to stimulate new research and enable inquiry at scales not previously possible. This is particularly true for ecology, where rapid…
Tadpole nerve regeneration capacity provides clue to treating spinal cord injury
Nagoya University researchers have identified a gene that plays a crucial role in regenerating neurons of African clawed frog tadpoles, which has an unusually high capacity for nerve regeneration. Their study, recently published in the journal iScience , showed that…
New statistical method eases data reproducibility crisis
The new tool enhances the replicability of large genomic datasets
Everyone poops: Monitoring COVID-19 in wastewater
University of Missouri scientists receive $4 million grant from the National Institutes of Health to examine clues about the rate of infection in communities and virus variants
Scientists identify virus-cell interaction that may explain COVID-19’s high infection rate
Lehigh researchers quantify the specific interaction between the spike protein of SARS-CoV-2 — the virus that causes COVID-19 — with the ACE2 receptors in human cells that may partially explain its high infection rate compared to SARS-CoV-1
AllianThera Biopharma comes out of stealth and collaborates on AI with Insilico Medicine
AllianThera Biopharma lead by ex-pharma veterans, Dr. Yuan-Hua Ding and Dr. Javier Cote-Sierra partnered with an AI-driven drug discovery company, Insilico Medicine to tackle cancer and autoimmune diseases
‘Keep off the grass’: the biofuel that could help us achieve net zero
The Miscanthus genus of grasses, commonly used to add movement and texture to gardens, could quickly become the first choice for biofuel production. A new study shows these grasses can be grown in lower agricultural grade conditions – such as…
Two new species of already-endangered screech owls discovered in Amazon rainforest
Recordings of owls’ screeches used to help tell species apart
Glycans are crucial in COVID-19 infection
A research group at the RIKEN Center for Computational Science (R-CCS) has found that glycans–sugar molecules–play an important role in the structural changes that take place when the virus which causes COVID-19 invades human cells. Their discovery, which was based…
New sequencing approach finds triple-negative breast cancers continue accumulating genetic changes during tumor growth
Novel technique for single-cell single-molecule DNA sequencing enables faster, deeper study of chromosome evolution with possible clinical and research implications
Viruses: Evolution on the outskirts
Despite the fact that viruses are among the simplest biological entities–consisting only of DNA or RNA encapsulated in a protein shell–they can have devastating consequences, with viruses such as influenza, human immunodeficiency virus (HIV), and Ebola having dramatically affected the…
Planting the seed for DNA nanoconstructs that grow to the micron scale
A concept for seeded all-or-nothing assembly of micron-scale DNA nanostructures that could extend nanofabrication capabilities and enable creation of highly specific diagnostics
Identifying rare genetic variants that increase risk for lung cancer
Lung cancer is the leading cause of cancer death in the U.S. for both men and women. While risk for this disease can be influenced by environmental and lifestyle factors like smoking, studies estimate that 18% of lung cancer cases…
Study of 630,000 patients unveils COVID-19 outcome disparities across racial/ethnic lines
Researchers examined EHRs of patients tested for SARS-CoV-2 and found stark disparities in COVID-19 outcomes — odds of infection, hospitalization, and in-hospital mortality — between White and non-White minority racial and ethnic groups
SARS-CoV-2 infects cells via specific viral entry factors
Viral entry factors are more abundant in elderly, men and smokers
Identifying cells to better understand healthy and diseased behavior
Graphical model an advance in common neuroscience bottleneck
Morris Animal Foundation, the Purina Institute join to study canine cognitive dysfunction
Morris Animal Foundation, a leader in advancing animal health, is partnering with the Purina Institute to advance the knowledge of canine cognitive dysfunction syndrome (CDS), through the Foundation’s Golden Retriever Lifetime Study . By collecting data from the Study’s dog…
Global warming helps invasive species flourish – study models likely combined effects on ecosystems
Increased global temperatures help invasive species establish themselves in ecosystems, new research led by a Swansea University bioscientist has shown. The study, published by the Royal Society, gives an insight into the probable combined effects of species invasions, which are…
The trouble of being tall
The giraffe is a truly puzzling animal. With its exceptional anatomy and suite of evolutionary adaptations, the giraffe is an outstanding case of animal evolution and physiology. Now, an international team of researchers from the University of Copenhagen and Northwestern…
A deep dive into cells’ RNA reality
New highly sensitive, specific, and multiplexable RNA detection method advances in situ transcriptomics with potential for a range of biomedical applications
Physicians and scientists join forces to develop the longevity medicine curriculum
Physicians and scientists highlight the importance of longevity medicine education and collaborate on the first longevity medicine course for physicians
Viruses adapt to ‘language of human cells’ to hijack protein synthesis
Findings may boost design of antiviral treatments, gene therapies and vaccines
New probe set unravels evolutionary history of second-most diverse group of land plants
In 2016, a collaborative group of research and education specialists received funding from the National Science Foundation for the project ‘Building a Comprehensive Evolutionary History of Flagellate Plants’ — also known as ‘Genealogy of Flagellate Plants’ (GoFlag). Members of the…
Enzymatic danse macabre of lung cancer
A chromatin-regulating enzyme has been shown by in-depth interdisciplinary investigations to be a key driver of a common type of lung cancer. Drugs that target the enzyme could improve treatment and survival rates for this particular cancer. “Squamous cell carcinoma…
Saarbrücken based bioinformaticians trace down molecular signals of Parkinson’s disease
In their study, which is now published in the journal Nature Aging , they show that the level of non-coding RNAs in the blood of a Parkinson’s patient can be used to track the course of the disease. For their…
Accurate aging of wild animals thanks to first epigenetic clock for bats
UMD-led research identifies age-related changes to DNA and reveals longevity-related differences between bat species
New proteins ‘out of nothing’
International team of researchers investigates how evolution forms the structure and function of a newly emerged protein in flies
A computational guide to lead cells down desired differentiation paths
A novel computer-guided design tool predicts combinations of transcription factors for more effective engineering of cell types with potential use in cell therapies and tissue modeling
Two Danforth Center Scientists Receive Prestigious Awards Recognizing Their Achievements And Leadership
Andrea Eveland received the Marcus Rhoades Early Career Award at the 63rd Maize Genetics Conference. Malia Gehan received the 2021 North American Plant Phenotyping Network (NAPPN) Early Career Award at the NAPPN annual conference.
Researchers test using environmental DNA to monitor grass pollen levels
Grass pollen is a major outdoor allergen, responsible for widespread and costly respiratory conditions including allergic asthma and hay fever (rhinitis). Now, researchers re-porting in the journal Current Biology on March 11 suggest that environmental DNA could help to better…
Two Danforth Center scientists receive prestigious awards
ST. LOUIS, MO, March 11, 2021 – Two Danforth Center Principal Investigators were recently recognized with early career awards for outstanding achievement and leadership. Andrea Eveland, Ph.D., associate member, received the Marcus Rhoades Early Career Award at the 63rd Maize…
Deforestation favors an increase in the diversity of antibiotic-resistant soil bacteria
Study analyzed some 800 million DNA sequences extracted from 48 soil samples collected in Pará State and northern Mato Grosso State, both of which are part of the Amazon biome
Simultaneous multicontrast OR-PAM from single laser source
Optical-resolution photoacoustic microscopy innovation enables simultaneous multicontrast imaging with shorter imaging time and improved accuracy
NIH researchers develop guidelines for reporting polygenic risk scores
Researchers hope the new approach will be used as a framework for publishing studies on polygenic risk scores
The 3Rs of the genome: Reading, writing, and regulating
A new map of protein binding locations in yeast advances understanding of gene regulation
First the treats, then the tough stuff: A bacterial dinner plan for degrading algal blooms
Metaproteomics enables new insights into the marine carbon cycle
Full evolutionary journey of hospital superbug mapped for the first time
Modern hospitals and antibiotic treatment alone did not create all the antibiotic resistant strains of bacteria we see today. Instead, selection pressures from before widespread use of antibiotics influenced some of them to develop, new research has discovered. By using…
A new predictive model helps identify those at risk for severe COVID-19
Buck scientists analyze data from 3 million people using a smartphone app in the United Kingdom
Gene discovery may help peaches tolerate climate stress
Researchers have identified genes in peach’s wild relatives and local domesticated varieties that could improve the resistance of domesticated peach to many pressures imposed by climate change
Amyloid plaque mutation map opens new avenues for early detection of Alzheimer’s disease
A study published in the journal eLife made all the possible mutations in the amyloid beta peptide and tested how they influence its aggregation into plaques, a pathological hallmark of Alzheimer’s disease. The comprehensive mutation map, which is the first…
Unveiling the cause of onion center rot
Since 1983, the bacteria Pantoea ananatis has been known to infect several important crops including onions, rice, and corn. It was unclear, however, what molecules were involved. A new study, published in mBio , has identified one of the culprits:…