Sulfatase 2 Plays Role in Development of Obesity-induced Fatty Liver Disease

Article title: Knockout of sulfatase 2 is associated with decreased steatohepatitis and fibrosis in a mouse model of nonalcoholic fatty liver disease

Authors: Tae Hyo Kim, Bubu A. Banini,* Faizal Z. Asumda, Nellie A. Campbell, Chunling Hu, Catherine D. Moser, Abdirashid M. Shire, Shaoshan Han, Chenchao Ma, Anuradha Krishnan, Taofic Mounajjed, Thomas A. White, Gregory J. Gores, Nathan K. LeBrasseur, Michael R. Charlton, Lewis Rowland Roberts

From the authors: “These data, along with work from other laboratories, suggest that [sulfatase 2] may be critical to the ability of the liver to progress to nonalcoholic steatohepatitis and fibrosis in conditions of overnutrition.”

This study is highlighted as one of September’s “best of the best” as part of the American Physiological Society’s APSselect program.