Stem cell transplantation and fertility in mice

A study of chemically castrated mice deficient in the Cldn11 gene, which regulates functioning of the blood-testis barrier, finds that transplantation of spermatogonial stem cells can restore the development of fertile sperm, suggesting that such stem cell transplantation may help treat some forms of male infertility, according to the authors.

Article #19-14963: “Autologous transplantation of spermatogonial stem cells restores fertility in congenitally infertile mice,” by Mito Kanatsu-Shinohara, Narumi Ogonuki, Shogo Matoba, Atsuo Ogura and Takashi Shinohara.

MEDIA CONTACT: Takashi Shinohara, Kyoto University, JAPAN; e-mail:

[email protected]

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