Researchers Use New Model to Predict Multiorgan Failure in Severe Pancreatitis

Article title: Severe acute pancreatitis: Capillary permeability model linking systemic inflammation to multiorgan failure

Authors: Nicole L. Komara, Pedram Paragomi, Phil J. Greer, Anette S. Wilson, Cameron Breze, Georgios I. Papachristou, David C. Whitcomb

From the authors: “With the use of the predictions of a new mechanistic model, we compared patients with severe acute pancreatitis with or without multiorgan failure. All biomarkers of capillary leak and clinical features of multiorgan failure were accurately predicted. This provides a new paradigm for understanding and developing new treatments for patients with severe acute pancreatitis.” 

This study is highlighted as one of November’s “best of the best” as part of the American Physiological Society’s APSselect program.