Regular Exercise May Protect Cardiovascular Cells during Chemotherapy

Marie Mclaughlin, MSc, from Edinburgh Napier University in Scotland, will present research on human endothelial cells treated with FEC-T, a chemotherapy regimen that combines four drugs (5 fluorouracil, epirubicin, cyclophosphamide and docetaxel). The researchers found that preconditioning the endothelial cells with serum (blood) from people who habitually exercise caused less cell death than samples that were treated with untrained serum (people who exercised less than 75 minutes per week). “Exercise preconditioning can provide protection against these detrimental effects in vitro,” Mclaughlin explained.

The research will be presented virtually at the American Physiological Society (APS) Integrative Physiology of Exercise (IPE) conference. Request the Abstract: “In Vitro HUVEC model of chronic exercise protection of vascular endothelial toxicity of FEC-T chemotherapy treatment for breast cancer using ex vivo serum preconditioning”