Prenatal Smoke Exposure Impairs Lung Development in Offspring through Increased Signaling

Article title: Prenatal smoke exposure dysregulates lung epithelial cell differentiation in mouse offspring – Role for AREG-induced EGFR signaling

Authors: Khosbayar Lkhagvadorj, Zhijun Zeng, Juan Song, Marjan Reinders-Luinge, Wierd Kooistra, Shanshan Song, Susanne Krauss-Etschmann, Barbro N. Melgert, Junjun Cao, Machteld N. Hylkema

From the authors: “The observed impaired bronchial and alveolar cell development in prenatally smoke-exposed neonatal offspring may be induced by increased AREG-EGFR signaling.”

This study is highlighted as one of October’s “best of the best” as part of the American Physiological Society’s APSselect program.